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  1. nitrosamines.usp.org › t › higher-limits-allowed-byHigher limits allowed by FDA for Nitroso-sitagliptin

    Aug 10, 2022 · The FDA said Tuesday that it recently became aware of a nitrosamine impurity, Nitroso-STG-19 or NTTP, in certain samples of Merck's type 2 diabetes drug Januvia. To avoid a shortage of the drug that pulled in more than $10.5 billion for Merck in 2020...

  2. www.secnav.navy.mil › doni › DirectivesDEPARTMENT OF THE NAVY

    (e) NTTP 3-13.3M/MCTP 3-32B, Operations Security (OPSEC) of . September 2017 (f) DoD Instruction 8550.01, DoD Internet Services and Internet- Based Capabilities of 11 September 2012 (g) DoD Instruction 5230.24, Distribution Statements on . Technical Documents of 23 August 2012 (h) DoD Instruction 5200.39, Critical Program Information (CPI)

  3. www.sciencedirect.com › science › articleCurrent Threat of Nitrosamines in Pharmaceuticals and ...

    May 1, 2023 · There is a concern about the nitrosamine impurity nitroso-STG-19 (7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo-[4,3-a]pyrazine or NTTP) in sitagliptin. 37, 38, 39 NTTP is generated by the reaction between nitrosating agents and the secondary amine, 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine used in the drug synthesis. The secondary amine can also ...

  4. www.fiercepharma.com › manufacturing › fda-anglesFDA relaxes impurity limit on Merck's Januvia after testing ...

    Aug 10, 2022 · The potential cancer agent Nitroso-STG-19, also known as NTTP, has surfaced in certain samples of Merck & Co.’s Type 2 diabetes blockbuster Januvia, the FDA said Tuesday. Januvia, also known as ...

  5. www.acronymfinder.com › Science-and-Medicine › NTTPNTTP - Science & Medicine - Acronym Finder

    Meaning. NTTP. No Tenderness to Percussion (dentistry) NTTP. Numerical Tokamak Turbulence Project. showing only Science & Medicine definitions ( show all 7 definitions) Note: We have 13 other definitions for NTTP in our Acronym Attic. new search. suggest new definition.

  6. www.sciencedirect.com › science › articleInhibition of N-Nitrosamine Formation in Drug Products: A ...

    Dec 1, 2021 · Separation of NTTP was achieved on a column Acquity HSS T3 using a mobile phase consisting of 0.1 % formic acid in water and methanol. Detection was performed using positive electrospray and multiple reaction monitoring at transitions m/z 222.15→42.05 (collision energy 17 eV) and m/z 222.15→192.15 (collision energy 11 eV). Two issues ...

  7. www.osmre.gov › programs › national-technicalNational Technical Training Program | Office of Surface ...

    Since 1985, the National Technical Training Program (NTTP) has provided ongoing education to increase the technical competence and professionalism of Federal, State, and Tribal personnel. Training serves to build the technical expertise of stakeholders and fosters consistent application of SMCRA standards. Training is provided in each of the ...