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  1. Erythrocytosis can be relative, transient, or absolute. Relative erythrocytosis occurs when a decrease in the volume of plasma (the liquid part of blood) results in an apparent increase in red blood cell numbers. Relative polycythemia can be caused by anything that causes fluid loss from the blood, such as dehydration from vomiting or diarrhea.

    • Anemia in Dogs

      Your pet's veterinarian may need to refer your dog to an...

    • Initial Presentation and Diagnostics
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    The patient was an 8-year-old intact male border collie presented to his primary care veterinarian for hematemesis. At the time of examination, mild preputial bleeding was noted. A complete blood count (CBC) revealed a markedly elevated hematocrit of 83%. Eight days later, after additional preputial bleeding was noted, a recheck CBC indicated a per...

    At the time of presentation to our referral hospital, no additional bleeding episodes were reported. Physical examination revealed moderate conjunctival hyperemia but was otherwise unremarkable, with no evidence of dehydration. An additional CBC indicated that the spun packed cell volume (PCV) was elevated at 76%; plasma protein was within referenc...

    After 500 mL of blood was removed by jugular phlebotomy, 800 mL of lactated Ringer’s solution was administered through a cephalic catheter. The PCV after phlebotomy was 65%. Two weeks later, the patient’s PCV had increased to 75% and another 500 mL of blood was removed from the jugular vein. PCV after the second phlebotomy was 55%. After the target...

    • Dehydration & Splenic Contraction (Relative Erythrocytosis) Dehydration. Dehydration causes hemoconcentration and decreased total intravascular fluid volume without decreased erythrocytes,7 resulting in an artifactual increase in hematocrit due to hemoconcentration.1.
    • Hypoxemia (Secondary Appropriate Absolute Erythrocytosis) Tissue hypoxia (eg, as a result of adjustment to high altitude, chronic pulmonary disease, cardiac disease, hemoglobin disorders, cardiac shunts, venoarterial shunts) stimulates increased release of erythropoietin, which may lead to secondary appropriate absolute erythrocytosis.
    • Erythropoietin-Secreting Neoplasms (Secondary Inappropriate Absolute Erythrocytosis) Secondary inappropriate absolute erythrocytosis can occur due to increased production of erythrocytes induced by an erythropoietin-secreting neoplasm; this is an inappropriate response because erythropoietin production is increased in the absence of systemic hypoxia.
    • Endocrinopathy-Associated Erythrocytosis (Secondary Absolute Erythrocytosis) Hormones (eg, cortisol in dogs, thyroxine and growth hormone in cats) can directly or indirectly stimulate erythropoiesis.
  2. Erythrocytosis, regularly used synonymously with polycythemia, is a disease in which the bone marrow produces too many red blood cells. The primary difference between erythrocytosis and polycythemia is that polycythemia may be linked to leukocytosis, thrombocytosis, and erythrocytosis. This disease is rare in dogs.

  3. Absolute erythrocytosis, defined as increased RBC numbers because of increased RBC mass, develops from primary or secondary causes. Primary erythrocytosis (polycythemia vera) is a myeloproliferative disease resulting from the autonomous clonal expansion of hematopoietic progenitor cells that has been reported in dogs, cats, horses, and ferrets ...

  4. The take-away message about erythrocytosis in dogs and cats… Erythrocytosis or polycythemia is defined as an increase in circulating red blood cells. There are many potential causes, and a proper diagnostic investigation. With timely identification and appropriate treatment, many patients can lead high quality lives.

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  6. Mar 25, 2024 · Polycythemia, erythrocytosis, and high red blood cell count are all used to describe the increase in RBC either in quantity, hemoglobin (protein that carries oxygen), or PCV. This increase in red blood cells causes them to collect on the walls of red blood vessels, also called sludging. This causes vessel damage, clot formation, and poor ...

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