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  2. Oct 8, 2019 · According to Mayo Clinic, the condition causes bursts of uncontrollable laughing or crying and usually manifests in people with ALS, MS, neurological conditions or traumatic brain injuries.

    • Pseudobulbar Affect
    • Mania and Hypomania
    • Hallucinations
    • Disorganized Motor Behavior
    • Psychogenic Laughter
    • Seizures
    • Tics
    • Stereotypies
    • Gelastic Cataplexy
    • Isolated Pathological Laughter

    The above-mentioned characteristics make the Joker’s laughing episodes compatible at first sight with the pseudobulbar affect, a clinical entity characterized by episodes of exaggerated or involuntary expression of emotions, including uncontrolled laughing or crying. The main proposed diagnostic criteria for pseudobulbar affect states that the emot...

    Mania is a clinical state consistent in elevated mood, energy, and activity. It is associated with symptoms such as inflated self-esteem, decreased need for sleep, verbosity, flight of ideas, distractibility, agitation, and reckless behavior. Manic episodes typically last oneweek and are present almost all day. Classically, mania is considered to b...

    Hallucinations are abnormal sensory perceptions that occur in the absence of an external object or stimulus. This symptom constitutes one of the five domains of the schizophrenia spectrum and other psychotic disorders . Hallucinations can occur with significant frequency in other psychiatric conditions (e.g., posttraumatic stress disorder, bipolar ...

    Disorganized or abnormal motor behavior is the inability to complete goal-directed activities. Patients are observed talking to themselves, becoming agitated in an unpredictable manner, or also undertaking what would be seen as inappropriate laughing or childlike behavior. Arthur Fleck’s disorganized behavior and complex hallucinations and delusion...

    Psychogenic non-epileptic seizures are involuntary paroxysmal behavioral, motor, sensory, autonomic, cognitive, or emotional changes resulting from psychological alteration. Clinical features of psychogenic non-epileptic seizures include spontaneous vocalizations such as moaning, grunting, gasping, screaming, and crying . Laughter has rarely been d...

    Seizures are paroxysmal clinical events secondary to abnormal excessive and synchronous neuronal activity. Signs and symptoms occurring during the paroxysm are wide and include alterations in mood and emotional expression . Focal emotional seizure with laughing or gelastic seizures consist of recurrent stereotyped laughter or similar vocalizations ...

    Tic disorders represent a spectrum of neurodevelopmental disorders usually beginning before 18 years of age. The clinical phenomena of tics consist of non-purposeful, repetitive, and patterned phonetic or motor behaviors, typically associated with preceding uncomfortable sensory experiences which are relieved by tic performance . In some cases, pho...

    Stereotypies are repetitive, seemingly driven, pseudo-purposeful motor behaviors usually beginning in the first decade of life. They may interfere with social, academic, or other activities and even result in self-injuries. Stereotypies may be primary (i.e., isolated) or secondary, appearing in association with other behavioral and cognitive sympto...

    Laughter is also part of the gelastic cataplexy, a clinical phenomenon characterized by episodes of sudden loss of muscle tone with collapse or falls occurring during laughter in people with Niemann Pick disease type C , which is a rare genetic lysosomal lipid storage disease with visceral, neurological, and psychiatric manifestations. This descrip...

    Finally, it cannot be ruled out that the disorder of pathological laughter might be linked to any of the drugs consumed by the character, whose names were not specified in the film. Isolated pathological laughter has been described with the use of paroxetine, ziprasidone, and valproic acid, among others .

    • Xavier Merchán-del-Hierro, Julián Fernandez-Boccazzi, Emilia M Gatto
    • 2021
  3. Oct 5, 2019 · In the film it's noted that the condition can be caused by brain damage, and in the third act the source of Arthur's brain injury - the likely cause of his uncontrollable laughing - is revealed. Related: Robert Downey Jr. Could Lose An Oscar To The Joker (Again)

    • Senior Editor-Star Wars
  4. Oct 4, 2019 · In 'Joker', Joaquin Phoenix plays Arthur Fleck, a man with pseudobulbar affect, a real medical condition that causes uncontrollable outbursts of laughter.

    • philip@freelancephilip.co.uk
    • 3 min
  5. Jan 6, 2020 · While Joker doesn't name Fleck's condition, nor any of the mental illnesses he's been medicated for, there is a real disorder that can cause fits of uncontrollable laughter. And tears. The real laughing disorder is called the Pseudobulbar Affect.

    • Samantha Vincenty
    • Senior Staff Writer
  6. Oct 9, 2019 · In Joker, Joaquin Phoenix plays Arthur Fleck, who laughs uncontrollably. The condition isn’t named, but it’s based on a real disorder called pseudobulbar affect.

  7. May 1, 2021 · And one element of his performance that had people talking was his ability to portray the character's struggle with mental illness and his uncontrollable laughter. But is the character's compulsive laughter a real medical condition?

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