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  1. en.wikipedia.org › wiki › PergolidePergolide - Wikipedia

    Pergolide. Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline -based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine synthesis in the substantia nigra of the brain. Pergolide acts on many of the same ...

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  3. Permax. Generic Name. Pergolide. DrugBank Accession Number. DB01186. Background. Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors.

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    The risk or severity of CNS depression ...
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  4. Jan 16, 2022 · Pergolide is used to treat Parkinson's disease although other treatments are often preferred to it because it is associated with a small risk of fibrotic reactions, as a side-effect of the treatment. Fibrotic reactions can lead to breathing difficulties, a persistent cough, chest pain, and tummy (abdominal) pain or tenderness (see the side-effects table below).

  5. Sep 28, 2023 · Use pergolide as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take by mouth only. Keep taking pergolide even when you are not having symptoms. Do not stop taking pergolide all of a sudden or lower your dose without talking to your doctor. Side effects may happen.

  6. USES: This medication is used to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome").Pergolide is an ergot medication that works by helping to restore the balance of ...

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  8. Pergolide is an agonist of D1 and D2 dopaminergic receptors. 346 In comparison with levodopa, which gradually loses its effectiveness during chronic use, pergolide at a dose of 2 mg/day improved PD symptoms and allowed patients to reduce the intake of levodopa dosage by as much as 50%. The adverse events of pergolide, although are manifested frequently, are mild and reversible.

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