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  2. Dec 20, 2022 · While further n-of-1 trials may help to clarify the nature and severity of reported myalgia, clear evidence indicates that statin associated muscle symptoms are uncommon and that most are not related to muscle damage.14

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    Statin myopathy generally takes one of three forms: 1. Myalgia:Muscle pain is the most common symptom experienced by people taking statins. Statin-induced myalgia is generally experienced as a soreness, usually in the shoulders and arms, or the hips and thighs. It is often accompanied by mild weakness. 2. Myositis: Muscle inflammation caused by sta...

    Muscle problems with statins are more common in people who are also taking Lopid (gemfibrozil), steroids, cyclosporine, or niacin. People who have chronic kidney disease, liver disease, reduced vitamin D levels, or hypothyroidismare also more likely to experience muscle problems with statins, as are people who have preexisting muscle disease. Some ...

    Generally, if a statin-related muscle problem is suspected, healthcare providers will stop the statin drug, at least until the muscle problem resolves. An assessment should be done for vitamin D deficiency and hypothyroidism, as well as for any drug interactions that may increase statin-related muscle problems. Any of these risk factors that are id...

    While muscle side effects are the most common problem seen with statins, these side effects are relatively infrequent in people who do not have additional risk factors. Furthermore, when they occur, muscle problems are almost always reversible. Life-threatening muscle problems from statins are extremely rare. Still, if you are taking a statin drugy...

  3. The findings explain why only some people experience muscle pain after taking statins and could help doctors to identify those most likely to experience symptoms so they can be offered alternative therapies.

  4. Mar 19, 2024 · Which muscles are most affected by statins? The muscles most affected by statins include those in the shoulders, arms, hips, or thighs. Myositis: Myositis, a type of myopathy, causes muscle pain and inflammation and an elevation in CK (a muscle enzyme) levels in the blood.

  5. May 16, 2022 · The most common complaint associated with statins, according to the American College of Cardiology, is myopathy, a muscle disorder, which may occur in up to a third of statin users....

  6. May 27, 2023 · Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause extreme muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low.

  7. N-of-1 trial evidence suggests that muscular symptoms attributed to statins are often caused by the nocebo effect. This article aims to provide a structured, evidence-based approach to suspected statin-related muscle toxicity. Keywords: Cardiovascular risk, creatine kinase, statin-associated muscle symptoms, statin-related muscle toxicity, statins

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