Search results
Dec 3, 2018 · Abstract. This review summarizes our current understanding of the major pathway for the initiation phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe the major scanning or messenger RNA (mRNA) m 7 G cap-dependent mechanism, which is a highly coordinated and stepwise regulated process that requires the ...
- Protein Synthesis Initiation in Eukaryotic Cells - PMC
We present a summary of the current knowledge of the...
- Mechanism of Translation Initiation in Eukaryotes - Madame ...
The initiation of protein synthesis consists in the...
- Protein Synthesis Initiation in Eukaryotic Cells - PMC
Protein synthesis is regulated at the initiation stage. Determining the structures and activities of initiation factors, and mapping their interactions in ribosomal initiation complexes, has ...
- Richard J. Jackson, Christopher U. T. Hellen, Tatyana V. Pestova
- 2010
Jul 17, 2023 · Protein factors– the process of protein synthesis requires multiple non-ribosomal proteins that transiently participate during the initiation, elongation, and termination phases of protein synthesis. These factors are named for the phase in which they function (for example, eukaryotic initiation factor 2, eIF2).
- Jacob E. Hoerter, Steven R. Ellis
- 2023/07/17
- 2021
We present a summary of the current knowledge of the molecular mechanisms enabling the initiation of protein synthesis in eukaryotic cells. We focus on the major m 7 G cap-dependent pathway, and only briefly consider alternative initiation routes. We cannot cover all the work that has been performed and so we focus primarily on more recent studies.
The initiation of protein synthesis consists in the recruitment of a ribosome·initiator tRNA complex to the initiation codon of a messenger RNA. In prokaryotes, this process involves the direct interaction of the ribosomal RNA with the mRNA. In contrast, eukaryotes have evolved a sophisticated mechanism that relies mostly on protein-RNA and protein-protein interactions. Eukaryotes have taken ...
- Francis Poulin, Nahum Sonenberg
- 2013
- 2013
Jun 5, 2012 · Translation initiation in eukaryotes is a complex and highly regulated process requiring the action of at least 12 protein factors. The pathway is distinguished by the formation of a pre ...
People also ask
Is protein synthesis regulated at the initiation stage?
What is the initiation of protein synthesis in prokaryotes?
What is the mechanism of translation initiation in eukaryotes?
What are protein factors?
Which initiation factors control translation initiation in bacteria and eukaryotes?
What are the initiation factors of ribosomal subunit eukaryotes?
Jul 21, 2013 · Three structures of the eukaryotic small ribosomal subunit in complex with initiator tRNA, mRNA and the initiation factors eIF1 and eIF1A have been solved; these structures offer insight into the ...
