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Phylogenies based on BLAST alone are less reliable than other purpose-built computational phylogenetic methods, so should only be relied upon for "first pass" phylogenetic analyses. DNA mapping When working with a known species, and looking to sequence a gene at an unknown location, BLAST can compare the chromosomal position of the sequence of interest, to relevant sequences in the database(s).
The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify ...
3 days ago · The Basic Local Alignment Search Tool (BLAST) finds regions of similarity between sequences. The program compares nucleotide or protein sequences and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.
- Elliott Smith
- 2015
Today, one of the most common tools used to examine DNA and protein sequences is the Basic Local Alignment Search Tool, also known as BLAST (Altschul et al., 1990). BLAST is a computer algorithm ...
The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between protein or nucleotide sequences. The program compares nucleotide or protein sequences to sequence in a database and calculates the statistical significance of the matches. This chapter first provides an introduction to BLAST and then describes the practical application of different BLAST programs based on ...
- David Wheeler, Medha Bhagwat
- 2007
Mar 17, 2021 · The BLAST algorithm. The steps are as follows: Split query into overlapping words of length W (the W-mers) Find a “neighborhood” of similar words for each word (see below) Lookup each word in teh neighborhood in a hash table to find the location in the database where each word occurs. Call these the seeds, and let S be the collection of seeds.
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What is the basic local alignment search tool (BLAST)?
Jul 1, 2004 · BLAST is a heuristic that finds short matches between two sequences and attempts to start alignments from these ‘hot spots’. In addition to performing alignments, BLAST provides statistical information to help decipher the biological significance of the alignment; this is the ‘expect’ value, or false-positive rate.
