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- Rats have a long history in medical research: they were the first mammalian species specifically domesticated to be used in the laboratory. Records dating back to the 1850s show these animals were derived from those bred by rat fanciers who collected them for their unique coat colours and behavioural characteristics.
theconversation.com/animals-in-research-rats-16634
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Jan 17, 2020 · The laboratory rat was the first mammal domesticated for research purposes. It is descended from wild Norway rats, Rattus norvegicus, which despite their name likely originated in Asia.
- Klaudia Modlinska, Wojciech Pisula
- 2020
1. Rats were used in research for the first time more than 200 years ago to understand human physiology and medicine. 200 years ago, the brown rat, Rattus norvegicus, was first used by scientists to understand human physiology and medicine, with early studies concentrating on the effects of food and oxygen deprivation.
Sep 19, 2024 · Historical texts indicate that brown rats were domesticated as companion “fancy rats” in Japan during the Edo period (early 17th century), and separately in the UK and France; both of these domestication pathways produced pelage variants still known today.
This breed was developed at the Wistar Institute in 1906 for use in biological and medical research, and is notably the first rat developed to serve as a model organism at a time when laboratories primarily used the house mouse (Mus musculus).
Feb 11, 2023 · In 1856, one of the first published rat experiments described the effect of an adrenalectomy in albino rats. It was in the 1890s that the first known rat research came to the U.S. with neuroanatomical studies at the University of Chicago.
- Emilie Le Beau Lucchesi
Feb 27, 2019 · For decades, lab rats and mice have been used to make great scientific and medical advances, from cancer drugs and HIV antiretrovirals to the yearly flu vaccine.
Sep 18, 2013 · Rats have a long history in medical research: they were the first mammalian species specifically domesticated to be used in the laboratory. Records dating back to the 1850s show these animals...