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Valproic acid (10–60 mg/kg, tid) has been used as an adjunct to phenobarbital and primidone in dogs with refractory seizures. It has also been used to treat aggressive behavior problems (see Psychotropic Agents). Common adverse effects include transient GI distress, alopecia, sedation, and vomiting. Hepatic failure is rare.
- Psychotropic Agents
Mood-stabilizing drugs (lithium, carbamazepine, and valproic...
- Psychotropic Agents
Feb 8, 2018 · Valproic acid (Depakene ®) has been used in dogs primarily when they are refractory to other medications. The use has declined after other drugs became available (see Sections Zonisamide, Gabapentin, and Levetiracetam), but it has been used in some dogs successfully.
- Phenobarbital.
- Potassium Bromide (Kbr).
- Zonisamide.
- Keppra® (levetiracetam).
- Others.
- Administration of Medications.
Phenobarbital is perhaps the most widely used anticonvulsant. It is administered two times per day. A patient on phenobarbital must have blood levels monitored periodically for therapeutic levels and to ensure the drug does not reach toxic levels in the bloodstream. Metabolism of the drug tends to vary widely on an individual basis; therefore, two ...
Potassium bromide is another frequently used anticonvulsant medication. It is administered by itself or in conjunction with phenobarbital. This is a chemical-grade substance administered orally with food either once or twice daily. The liver does not metabolize bromide, and thus much of the chemical is passed in the urine and to a lesser degree in ...
Zonisamide is a newer effective anticonvulsant medication. It is a safe drug that has few side effects. The drug is well tolerated and is given twice a day. The most common side effect is a transient sedation at the beginning of the treatment. Although metabolized by the liver, hepatotoxicity has not been reported and there is no increment of the l...
Keppra is also a newer anticonvulsant drug with minimal side effects. Based on clinical experience, the transient sedation observed with this drug is more severe than with zonisamide. The drug is given three times a day. We do not recommend regular serum level monitoring as the margin of safety for this drug is wide and the response to treatment do...
Other anticonvulsant drugs are available for the control of seizures in dogs. These include the benzodiazepine family, gabapentin, valproic acid and felbamate. Because of resistance, side effects or increased frequency of administration, these drugs are not our primary choice for the treatment of seizures in dogs. In some circumstances, they can be...
Some important factors to remember when your pet is on anticonvulsant medication include: 1. Compliance with directions. Proper dosages must be given at regular, on-time intervals. Missing or being late with just one dose may be enough to trigger a cycle of seizure activity. 2. Make a chart, or log, of any and all seizure activity experienced by yo...
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Adjust dosage in all species by monitoring serum levels and seizure diary. Dogs: 2–4 mg/kg, PO, bid (starting dose); up to 10 mg/kg, bid. 40–90 hr (Beagles 25–38 hr) 10–24 days. 15–45 mcg/mL (66–200 μmol/L), preferably keep values within 20–35 mcg/mL (85–150 μmol/L)
Aug 28, 2015 · Several AEDs of the older generation approved for humans have been shown to be unsuitable for use in dogs as most have an elimination half-life that is too short to allow convenient dosing by owners, these include phenytoin, carbamazepine, valproic acid, and ethosuximide .
- Sofie F.M. Bhatti, Luisa De Risio, Karen Muñana, Jacques Penderis, Veronika M. Stein, Andrea Tipold,...
- 2015
Jul 18, 2016 · Valproate is used, usually in combination with phenobarbital, to treat refractory epilepsy in animals. Most use has been in dogs, but limited efficacy studies have been reported.
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What is valproic acid used for in dogs?
Is valproic acid an antiepileptic drug?
Are there any anticonvulsant drugs for seizures in dogs?
Which anticonvulsant drugs are used in veterinary medicine?
Is Keppra a good anticonvulsant for dogs?
What are the different types of anticonvulsant medications for pets?
Mood-stabilizing drugs (lithium, carbamazepine, and valproic acid) are unrelated chemical compounds used in human medicine to treat bipolar disorder, impulsivity, emotional reactivity, and aggression. Carbamazepine and valproic acid are also antiepileptic drugs.
