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- In budding yeast, certain autonomously replicating sequences (ARSs) initiate the replication as ORIs, maintaining the stability of chromosomes and plasmids during genome replication.
May 6, 2021 · The initiation of yeast chromosome replication depends on ARSs. Further decoding the potential molecular mechanisms of ARSs will deepen the understanding of the fundamental process of DNA replication, and also enable us to regulate yeast to produce chemicals efficiently by controlling ARSs.
- 1
- 21, Issue7
- 06 May 2021
The kinases Cdc7 [85, 86] and Cdk2 [72] play critical roles in the assembly and activation of pre-replication complexes in human cells (figure 1c) and as such their regulation determines the initiation of DNA replication. CMG helicase activation in yeast and human cells requires MCM phosphorylation by Cdc7/DDK.
- Tatiana N. Moiseeva, Christopher J. Bakkenist
- 10.1016/j.dnarep.2018.09.003
- 2018
- 2018/12
Initiation of DNA replication in yeast appears to operate through a two-step process. The first step occurs at the end of mitosis in the previous cell cycle, where, following the decrease in B cyclin-dependent kinase activity, an extended protein complex called the prereplicative complex (pre-RC) fo ….
- W M Toone, B L Aerne, B A Morgan, L H Johnston
- 1997
The mechanism of initiation of DNA replication in yeasts thus appears similar to that in prokaryotes and eukaryotic viruses; that is, an initiator protein specifically binds to origin sequences. Figure 5.17
- Geoffrey M Cooper
- 2000
Oct 14, 2020 · DNA replication in eukaryotic cells initiates from replication origins that bind the Origin Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence motifs in...
- Y. Hu, Y. Hu, A. Tareen, Y. J. Sheu, W. T. Ireland, C. Speck, H. Li, L. Joshua-Tor, L. Joshua-Tor, J...
- 2020
Mar 25, 2015 · The in vitro reconstitution of DNA-replication initiation in yeast allows mechanistic studies of this fundamental process.
Jan 1, 2002 · DNA synthesis is initiated at discrete sites of the genome called origins of replication on which a prereplicative complex (pre-RC) of different protein subunits is formed during the G 1 phase of the cell division cycle. Only after pre-RCs are formed is the genome competent to be replicated.
