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Nov 21, 2023 · Antimicrobial resistance (AMR) is one of the top global public health and development threats. It is estimated that bacterial AMR was directly responsible for 1.27 million global deaths in 2019 and contributed to 4.95 million deaths (1). The misuse and overuse of antimicrobials in humans, animals and plants are the main drivers in the ...
Sep 16, 2024 · Most future treatments in the later stages of drug development are derivatives of established antimicrobial classes, 56 and the development of resistance or cross-resistance already present has consistently proven problematic, 57 with resistance often shown before an antibiotic is commercially released. 58 Our estimates support the critical designation of carbapenem-resistant Enterobacterales ...
Feb 12, 2022 · The global burden associated with drug-resistant infections assessed across 88 pathogen–drug combinations in 2019 was an estimated 4·95 million (95% UI 3·62–6·57) deaths, of which 1·27 million (0·911–1·71) deaths were directly attributable to drug resistance.
Mar 23, 2022 · The global distribution of antibiotic resistance is related to the prediction of the abundance of ARGs in each country and territory by Hendriksen et al. 5. For example, the ARG risks in the ...
Sep 28, 2024 · Additionally, we produced global and regional forecasts of AMR burden until 2050 for three scenarios: a reference scenario that is a probabilistic forecast of the most likely future; a Gram-negative drug scenario that assumes future drug development that targets Gram-negative pathogens; and a better care scenario that assumes future improvements in health-care quality and access to appropriate ...
May 23, 2024 · Antimicrobial resistance: an enormous, growing, and unevenly distributed threat to global health. Each year, an estimated 7·7 million deaths are associated with bacterial infections, 1·27 million of which are caused by bacterial pathogens resistant to the antibiotics available to treat them. Rising antimicrobial resistance has been documented ...
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Antimicrobial resistance is an urgent global health and socioeconomic crisis. An estimated 1.27 million global deaths were attributed to drug-resistant bacterial infections in 2019. Antimicrobial resistance threatens all age groups in all regions, with low- and middle-income countries most affected.
