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- The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes into the two daughter cells during cell division, which is paramount for maintaining genome integrity. It is a self-organized and dynamic macromolecular structure that is constructed from microtubules, microtubule-associated proteins and motor proteins.
www.nature.com/articles/nrm.2016.162Mitotic spindle assembly in animal cells: a fine balancing act
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Sep 21, 2004 · Introduction. Essential to the process of cell division is the mitotic spindle, which partitions a complete set of chromosomes to each daughter cell. The spindle consists of microtubules, polar dynamic fibers that polymerize from tubulin subunits, as well as hundreds of other proteins that function together to orchestrate chromosome segregation.
- Mechanobiology of the Mitotic Spindle
The mitotic spindle is a microtubule-based assembly that...
- Mechanobiology of the Mitotic Spindle
In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis , a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis , a process ...
Nov 21, 2023 · The function of the mitotic spindle is to help to equally divide the chromosomes in the parent cell to ensure that equal, identical copies are found in both daughter cells after...
- The mitotic spindle is composed of hundreds or even thousands of microtubules. Microtubules, long polymers of tubulin, are critical in the cell's c...
- The mitotic spindle is formed from centrioles during the prophase phase of mitosis and is located within the dividing cell, surrounding the dividin...
- Mitotic spindle formation is a critical event that takes place during prophase. These spindle fibers are necessary to equally divide the chromosome...
INTRODUCTION. Life depends on cell proliferation. This occurs via cell division, during which a single cell generates two daughters, each of which retains the same genetic blueprint packaged into chromosomes via reliable chromosome segregation.
Jan 25, 2021 · The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together ...
- Nenad Pavin, Iva M. Tolić
- 2021
Feb 8, 2017 · The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes into the two daughter cells during cell division, which is paramount for maintaining genome...
The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during both types of nuclear division: mitosis and meiosis. During mitosis, the spindle...
