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Cause cells to divide and replicate uncontrollably
bio1220.biosci.gatech.edu
- PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer.
www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer
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What is PIK3CA gene?
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Mar 1, 2024 · PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer.
- Jacquelyn Cafasso
Oct 3, 2022 · The PIK3CA gene provides instructions for making the protein known as p110α, and mutations in this gene result in an abnormally active PI3K enzyme. With this increase in activity, affected cells grow and divide more than they should, leading to abnormal bone, soft tissue and blood vessel growth.
The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and related health conditions.
Feb 2, 2024 · PIK3CA gene mutations are genetic changes found in some breast cancers (as well as other cancers) that appear to promote the growth of the tumors. PIK3 (phosphoinositide 3-kinase), the protein produced by this gene, is part of a signaling pathway that has been studied extensively in the hope of halting the growth of metastatic breast cancer.
PIK3CA is a gene that encodes one piece (a subunit) of an enzyme called phosphatidylinositol 3-kinase. PIK3CA plays a role in the way cell growth, cell survival, and cell migration are controlled. Mutations in the PIK3CA gene can lead to uncontrolled cell growth and may cause cancer as well as some rare diseases of abnormal growth.
Oct 2, 2024 · PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PIK3CA include Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome and Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi.
Aug 15, 2013 · PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia.
