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The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence . The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
Nov 14, 2014 · The Hayflick Limit is a concept that helps to explain the mechanisms behind cellular aging. The concept states that a normal human cell can only replicate and divide forty to sixty times before it cannot divide anymore, and will break down by programmed cell death or apoptosis.
Apr 16, 2024 · The Hayflick limit refers to the maximum number of times a cell can divide. It's named after scientist Leonard Hayflick, who discovered this phenomenon. The limit plays a crucial role in aging and the development of age-related diseases.
The Hayflick limit was originally reported for human diploid fibroblasts which can divide a finite number of times before undergoing growth arrest and senescence (Hayflick, 1965). Mechanistically, the Hayflick limit reflects telomere shortening during each fibroblast replication.
Oct 1, 2000 · Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick...
- Jerry W. Shay, Woodring E. Wright
- 2000
Leonard Hayflick introduced the hayflick limit as the number of times a cell population can divide until it attains a cell cycle arrest. It is found to correlate with end regions of DNA strand called telomeres as telomeres get shorter by each cell division.
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'.
