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- A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
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Sep 23, 2021 · Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
- Peaks and troughs are the highest and lowest concentrations of a medication in an individual’s body. They are used to determine dosing intervals, o...
- The time to take peak levels depends on the route of administration. The peak level is taken about 15 to 30 minutes after intravenous injections or...
- Peaks and troughs are the highest and lowest concentrations, respectively, of a medication in an individual’s body. They are used to determine dosi...
In medicine and pharmacology, a trough level or trough concentration (C trough) is the concentration reached by a drug immediately before the next dose is administered, [1] [2] often used in therapeutic drug monitoring.
A trough level is drawn when the drug is at its lowest in the bloodstream, right before the next scheduled dose is given. Medications have a predicted reference range of normal values for peak and trough levels.
- 2023
The trough levels are the most reliable measurement of drug elimination and more closely reflect the potential for drug accumulation in patients with renal failure. Knowing the potential a drug has for direct renal toxicity is important in patients with decreased renal function. Read more. View article. https://www.sciencedirect.com/science ...
May 24, 2021 · The timing of blood collection is an important part of therapeutic drug monitoring. After a person takes a dose of drug, the amount in the blood rises for a short period of time, reaches a peak and then begins to fall, usually reaching its lowest level (the ‘trough level’) just before the next dose.
A trough level can be pertinent when the concentration–effect relationship suggests that efficacy (or toxicity) of a drug is linked to the maintenance of blood concentrations above a predefined targeted concentration (glycopeptides, antiviral or antiretroviral drugs, for instance). From: Therapeutic Drug Monitoring, 2012
Trough concentrations can be measured to determine drug accumulation and to reduce the risk of toxicity. Trough samples must be interpreted in the context of the time after the dose when the sample was drawn.
