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   What is PIK3CA treatment?

   • The Food and Drug Administration (FDA) has approved a treatment called alpelisib (Piqray) specifically for people with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative MBC whose tumors have a PIK3CA mutation. What is the PIK3CA gene?

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   Can PIK3CA mutations be treated with Piqray?

   • Patients with HR+/HER2- advanced breast cancer can be selected for treatment with Piqray based on the presence of PIK3CA mutations. Concurrent with the approval of Piqray, the therascreen ® * PIK3CA companion diagnostic test from QIAGEN was also approved by the FDA and is now available for patient testing.

   FDA approves Novartis Piqray® - the first and only treatment

   www.novartis.com/news/media-releases/fda-approves-novartis-piqray-first-and-only-treatment-specifically-patients-pik3ca-mutation-hrher2-advanced-breast-cancer

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   How does a PIK3CA test work?

   • For this test, a healthcare professional either takes a blood sample or a small amount of cancer tissue from your tumor and sends it to a lab. If the test results show the presence of a mutation in the PIK3CA gene in the cancer tissue, you are eligible for treatment with alpelisib (Piqray).

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   What is a PIK3CA mutation?

   • A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer (MBC). If your tumor has a PIK3CA mutation, new treatments that specifically target this mutation could be used to treat your cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   Does PIK3CA cause cancer?

   • In addition to playing a role in many breast cancers, PIK3CA mutations have been noted in a dozen other cancers, particularly uterine cancer, bladder cancer, colon cancer, and head and neck cancers.

   PIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488

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   Does PIK3CA mean if you have triple-positive breast cancer?

   • A 2022 study found the 5-year overall survival for triple-positive breast cancer was 96.7% within the study group. If you have MBC, knowing your PIK3CA gene status can be helpful if your cancer hasn’t improved or has come back after treatment, especially if you have HR-positive and HER2-negative breast cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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2. www.healthline.com › health › metastatic-breastPIK3CA Mutation in Metastatic Cancer: Treatment and More

   www.healthline.com › health › metastatic-breast

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   Mar 1, 2024 · The Food and Drug Administration (FDA) has approved a treatment called alpelisib (Piqray) specifically for people with hormone receptor (HR)-positive and human epidermal growth factor...

   • Author: Jacquelyn Cafasso

3. www.healthline.com › health › pik3ca-relatedPIK3CA-Related Overgrowth Spectrum Treatment - Healthline

   www.healthline.com › health › pik3ca-related

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   Feb 1, 2024 · Takeaway. While there’s no cure for PIK3CA-related overgrowth spectrum, treatment ranging from medications to surgery can help manage symptoms. PIK3CA-related overgrowth spectrum (PROS)...

4. Videos

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     Why Do Cancers Have PIK3CA Mutations and How Can They Be Targeted for Cancer Treatment?

     20 Sep 2023

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     PIK3CA-Related Overgrowth Syndrome (PROS) Explained

     23 Aug 2022

     817 views

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     rarediseases.org

     PIK3CA-Related Overgrowth Spectrum - Symptoms, Causes, Treatment | NORD

     1 Mar 2022

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5. www.verywellhealth.com › pik3ca-mutations-inPIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com › pik3ca-mutations-in

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   Feb 2, 2024 · PIK3CA mutations are important in both the development and progression of some breast cancers. Learn about the characteristics and treatment options.

6. pmc.ncbi.nlm.nih.gov › articles › PMC8664971A standard of care for individuals with PIK3CA-related ...

   pmc.ncbi.nlm.nih.gov › articles › PMC8664971

   We recommend following standard guidelines for treatment such as those established by the International League Against Epilepsy (ILAE) and referral to an epileptologist or epilepsy centre, for additional considerations such as ketogenic diet or epilepsy surgery (Glauser et al., 2013; Wilmhurst et al., 2015 and Kwan et al., 2010)

7. www.nejm.org › doi › fullAlpelisib for PIK3CA -Mutated, Hormone Receptor–Positive ...

   www.nejm.org › doi › full

   May 15, 2019 · Treatment with alpelisib–fulvestrant prolonged progression-free survival among patients with PIK3CA -mutated, HR-positive, HER2-negative advanced breast cancer who had received...

   • Author: Fabrice André, Eva Ciruelos, Gabor Rubovszky, Mario Campone, Sibylle Loibl, Hope S Rugo, Hiroji Iwat...

   • Publish Year: 2019

8. www.webmd.com › a-to-z-guides › pros-treatmentsTreatment for PIK3CA-Related Overgrowth Spectrum (PROS) - WebMD

   www.webmd.com › a-to-z-guides › pros-treatments

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   Mar 31, 2024 · PIK3CA-related overgrowth spectrum (PROS) syndromes vary widely, and treatment depends on how a child’s condition affects their body. Learn about the options that can help you manage your child...

9. www.novartis.com › news › media-releasesFDA approves Novartis Piqray® - the first and only treatment ...

   www.novartis.com › news › media-releases

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   May 24, 2019 · Piqray is a kinase inhibitor approved in combination with fulvestrant for the treatment of postmenopausal women, and men, with HR+/HER2-, PIK3CA-mutated, advanced or metastatic breast cancer, as detected by an FDA-approved test following progression on or after endocrine-based regimen [1].