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May 4, 2023 · It was first described by the American pathologist Dr Maurice Richter in 1928 as a reticular cell sarcoma 1 and the condition was later named in his honor in 1964. 2 Incremental progress was made with the utilization of multiagent chemoimmunotherapy (CIT) regimens, such as rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), although outcomes are far poorer than ...
Jul 5, 2023 · Dr. Joel D. Richter, PhD, the Arthur F. Koskinas Chair in Neuroscience and professor of molecular medicine Fragile X syndrome is a genetic condition resulting from a CGG repeat expansion in the ...
Jan 9, 2024 · Purpose of Review This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter’s transformation (RT). Recent Findings Recently, numerous approaches have been investigated for the treatment of RT including: traditional chemoimmunotherapy regimens combined with targeted agents such as BTKi and BCL2i; immunotherapy combined with ...
Feb 12, 2024 · Richter’s transformation (RT), also known as Richter’s syndrome, is a complication of chronic lymphocytic leukaemia (CLL) and/or small lymphocytic lymphoma (SLL). RT is sudden and occurs in approximately 2 to 10% of CLL patients and can happen at any stage of the disease. It transforms a usually slow-growing CLL into a much more aggressive ...
5 days ago · In this interview, Dr. Brian Koffman spoke with Dr. Adam Kittai, an associate professor of medicine at Mount Sinai. They discussed the role of haemopoietic stem cell transplants in treating Richter’s transformation. What is a stem cell transplant? “Blood stem cells are found in the bone marrow and can produce any type of blood cell the body ...
Dec 9, 2023 · Chronic lymphocytic leukemia (CLL) is classified as an indolent B cell non-Hodgkin lymphoma according to the World Health Organization classification and is the most common type of leukemia in ...
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Does Richter transformation improve survival in patients with chronic lymphocytic leukemia (CLL)?
What is the outcome of Richter transformation?
Does the genetics of Richter syndrome predict survival after transformation?
Is Richter transformation early seeding in chronic lymphocytic leukemia?
How do you know if you have Richter transformation?
Is Richter syndrome heterogeneous?
Introduction. Richter transformation (RT) refers to the transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma. It was first described by Dr. Maurice Richter in 1928 with a rapidly fatal case of “reticular cell sarcoma of lymph nodes” arising in the background of “lymphatic leukemia”. 1 RT presents with diffuse large B-cell lymphoma (DLBCL) in over 90% of the ...
