Drug discovery platform for NASH treatment. Therapeutic strategies targeting inflammation. Inflammasome Inhibitors, Chemokine Antagonists, Targeting Inflammation Resolution, etc.
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Inducers
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- The inflammatory pathway involves inducers, sensors, mediators, and effectors. Inducers initiate the inflammatory process, including infectious organisms or noninfectious stimuli such as foreign bodies and signals from damaged tissues or necrotic cells.
www.ncbi.nlm.nih.gov/books/NBK556083/
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Jun 8, 2024 · Inducers initiate the inflammatory process, including infectious organisms or noninfectious stimuli such as foreign bodies and signals from damaged tissues or necrotic cells. These inducers activate sensors, which are specialized molecules that stimulate the mediators.
- Sally Hannoodee, Dian N. Nasuruddin
- 2024/06/08
- 2020
May 18, 2021 · What happens when you have an inflammation. When an inflammation occurs in your body, many different immune system cells may be involved. They release various substances, known as inflammatory mediators. These include the hormones bradykinin and histamine.
- 2021/05/18
- Overview
- Causes
- Signs
- Vascular changes
•Redness is caused by the dilation of small blood vessels in the area of injury.
•Heat results from increased blood flow through the area and is experienced only in peripheral parts of the body such as the skin. Fever is brought about by chemical mediators of inflammation and contributes to the rise in temperature at the injury.
•Swelling, called edema, is caused primarily by the accumulation of fluid outside the blood vessels.
•The pain associated with inflammation results in part from the distortion of tissues caused by edema, and it also is induced by certain chemical mediators of inflammation, such as bradykinin, serotonin, and the prostaglandins.
The factors that can stimulate inflammation include microorganisms, physical agents, chemicals, inappropriate immunological responses, and tissue death. Infectious agents such as viruses and bacteria are some of the most common stimuli of inflammation. Viruses give rise to inflammation by entering and destroying cells of the body; bacteria release ...
The four cardinal signs of inflammation—redness (Latin rubor), heat (calor), swelling (tumor), and pain (dolor)—were described in the 1st century ad by the Roman medical writer Aulus Cornelius Celsus. Redness is caused by the dilation of small blood vessels in the area of injury. Heat results from increased blood flow through the area and is experienced only in peripheral parts of the body such as the skin. Fever is brought about by chemical mediators of inflammation and contributes to the rise in temperature at the injury. Swelling, called edema, is caused primarily by the accumulation of fluid outside the blood vessels. The pain associated with inflammation results in part from the distortion of tissues caused by edema, and it also is induced by certain chemical mediators of inflammation, such as bradykinin, serotonin, and the prostaglandins.
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A fifth consequence of inflammation is the loss of function of the inflamed area, a feature noted by German pathologist Rudolf Virchow in the 19th century. Loss of function may result from pain that inhibits mobility or from severe swelling that prevents movement in the area.
When tissue is first injured, the small blood vessels in the damaged area constrict momentarily, a process called vasoconstriction. Following this transient event, which is believed to be of little importance to the inflammatory response, the blood vessels dilate (vasodilation), increasing blood flow into the area. Vasodilation may last from 15 minutes to several hours.
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Next, the walls of the blood vessels, which normally allow only water and salts to pass through easily, become more permeable. Protein-rich fluid, called exudate, is now able to exit into the tissues. Substances in the exudate include clotting factors, which help prevent the spread of infectious agents throughout the body. Other proteins include antibodies that help destroy invading microorganisms.
- The Editors of Encyclopaedia Britannica
Inflammation is the mechanism of human diseases displaying the five classic inflammatory signs: redness, swelling, heat, pain and subsequent loss of organ function (Figure 1). Aulus Cornelius Celsus and his followers already described these signs in the 1st and 2nd century AD.
Inflammatory cells travel to the site of injury (like a cut on your finger) or infection and start the healing process. Infections in different parts of your body can cause sudden, and usually short-lived, inflammation.
The main function of inflammation is to trigger an immune response in an area of the body that needs it to fight off pathogens that may cause an infection or to help heal an injury. The main symptoms of acute inflammation are swelling, redness, pain, loss of function, and heat.
Mar 27, 2023 · Acute inflammation is the body’s protective response to an injury or infection. For example, when you cut your finger, your body dispatches white blood cells to protect the area. You may see and feel swelling, redness, and pain, but this process is critical to fighting infection.
