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1. • Receptor molecule

     • A chemical substance that binds to a receptor molecule and exhibits a function similar to that of a biological ligand such as a neurotransmitter.
     www.sciencedirect.com/topics/neuroscience/ergoline

     Ergoline - an overview | ScienceDirect Topics

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   What does ergoline bind to?

   • View More... 212.29 g/mol Ergoline is an indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors.

   Ergoline | C14H16N2 | CID 6857537 - PubChem

   pubchem.ncbi.nlm.nih.gov/compound/ergoline

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   What are ergoline alkaloids?

   • Ergoline alkaloids are naturally occurring compounds that consist of the privileged tetracyclic ergoline scaffold (Fig. 10, in red). First isolated from the fungus ergot, 158 these alkaloids have a long history in the field of medicine.

   Ergoline - an overview | ScienceDirect Topics

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   What is Ergoline Kinase?

   • Ergoline is a compound that is a basic structure of various ergoline alkaloids. It is also known as a serine/threonine protein kinase that is activated by various stimuli such as cell proliferation, differentiation, and oxidative stress. Alternatively, it is called neurotrophic factors.

   Ergoline - an overview | ScienceDirect Topics

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   Does phenethylamine lose activity in ergolines?

   • In contrast to phenethylamine hallucinogens, the structural requirements for activity in the ergolines are narrowly restricted, and if the chirality at either the 5- or the 8-position is reversed, activity is lost. The stereochemistry illustrated here is critical for activity.

   Ergoline - an overview | ScienceDirect Topics

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   What are ergoline derivatives?

   • The ergoline derivatives can be subdivided into three classes, lysergic acid amides that are water-soluble, ergopeptines (i.e., ergopeptides) that are water-insoluble, and the clavine group (Fig. 8) . Fig. 8. Derivatives of ergoline. The clavine ergolines or agro-clavines like festuclavine show cytostatic activities.

   Ergoline - an overview | ScienceDirect Topics

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   What is the chemical structure of ergopeptine alkaloids?

   • Ergopeptine alkaloids (ergopeptides, such as ergotamine) are composed of lysergic acid and a tripeptide moiety that is condensed to a tricyclic system. Ergopeptams are similar to ergopeptine alkaloids. FIGURE 39.18. Chemical structure of selected ergot alkaloids and dopamine. Most ergot alkaloids have a tetracyclic ergoline ring system.

   Ergoline - an overview | ScienceDirect Topics

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3. www.healthline.com › health › parkinsons-diseaseDopamine Agonists: Common Uses, Side Effects, and More

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   Dec 6, 2019 · Dopamine agonists bind to the D1 and D2 group of dopamine receptors in the brain, copying the effects of the neurotransmitter in order to improve disorders that happen from low levels.

4. www.sciencedirect.com › ergolineErgoline - an overview | ScienceDirect Topics

   www.sciencedirect.com › ergoline

   Ergoline are ligands for serotonin receptors and hence have a potential of the dopaminergic, anti-dopaminergic, serotonergic and anti-serotonergic activity. This varied functional profile can be attributed to them having the features of monoamine neurotransmitters 5-HT, noradrenaline and dopamine [ 38 ].

5. www.sciencedirect.com › topics › neuroscienceErgoline - an overview | ScienceDirect Topics

   www.sciencedirect.com › topics › neuroscience

   Each neurotrophin binds to a specific tropomyosin receptor kinase receptor (tropomyosin receptor kinase A for nerve growth factor, tropomyosin receptor kinase B for brain-derived neurotrophic factor and neurotrophin-4, and tropomyosin receptor kinase C for neurotrophin-3).

6. www.ncbi.nlm.nih.gov › books › NBK551686Dopamine Agonists - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK551686

   Jun 26, 2023 · Dopamine is an important neurotransmitter regulating voluntary movement, reward and addictive behavior, moods such as mania and depression, cognition, memory, learning, sleep, and food intake. Dopamine also inhibits the synthesis and secretion of prolactin from the pituitary gland.

   • Author: Jaehwa Choi, Kristen Ashley Horner

   • Published: 2023/06/26

7. pubchem.ncbi.nlm.nih.gov › compound › ergolineErgoline | C14H16N2 | CID 6857537 - PubChem

   pubchem.ncbi.nlm.nih.gov › compound › ergoline

   Ergoline is an indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors. It is an ergoline alkaloid, a diamine, an ...

8. www.nature.com › articles › s41598/020/66358-2Ergot alkaloid mycotoxins: physiological effects, metabolism ...

   www.nature.com › articles › s41598/020/66358-2

   Jun 16, 2020 · The ergoline nucleus (Fig. 2) of ergot alkaloids is structurally similar to the biogenic amines, dopamine, serotonin and adrenaline and consequently ergot alkaloids are able to act on the ...

9. www.sciencedirect.com › ergolineErgoline - an overview | ScienceDirect Topics

   www.sciencedirect.com › ergoline

   The ergoline-derived hallucinogen lysergic acid N, N -diethylamide (LSD). The stereochemistry illustrated here is critical for activity, and if the chirality at either the 5- or the 8-position is reversed, activity is lost.