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Cause cells to divide and replicate uncontrollably
bio1220.biosci.gatech.edu
- PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer.
www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer
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Mar 1, 2024 · PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer. Lordn /...
- Jacquelyn Cafasso
Feb 2, 2024 · PIK3CA gene mutations are genetic changes found in some breast cancers (as well as other cancers) that appear to promote the growth of the tumors. PIK3 (phosphoinositide 3-kinase), the protein produced by this gene, is part of a signaling pathway that has been studied extensively in the hope of halting the growth of metastatic breast cancer.
PIK3CA gene. phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Normal Function. The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K).
PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis.
- Ken Lai, Murray C Killingsworth, Cheok Soon Lee
- 2015
Keywords: PIK3CA-related overgrowth spectrum, clinical management, mosaic, expert consensus. INTRODUCTION. Activating variants in PIK3CA cause a phenotypic spectrum of developmental disorders known as the PIK3CA-Related Overgrowth Spectrum (PROS) (1-10). Deep sequencing technologies have facilitated the identification and clinical testing for ...
Aug 8, 2022 · PIK3CA encodes the class I PI3Kα isoform and is frequently mutated in cancer. Activating mutations in PIK3CA also cause a range of congenital disorders featuring asymmetric tissue overgrowth,...
Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis.
