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Jun 7, 2021 · On 30 December 1961, a paper was published in Nature that became an instant classic of molecular biology [].It combined theory and experimentation in a striking display of the incisive thinking of the first author, Francis Crick, and of his intensely productive interactions with his friend, colleague and co-author, Sydney Brenner [].
- Matthew Cobb
- 2021
The Crick, Brenner et al. experiment (1961) was a scientific experiment performed by Francis Crick, Sydney Brenner, Leslie Barnett and R.J. Watts-Tobin. It was a key experiment in the development of what is now known as molecular biology and led to a publication entitled "The General Nature of the Genetic Code for Proteins" and according to the historian of Science Horace Judson is "regarded ...
Jun 7, 2021 · statement has been added.] Abstract. In 1961, Francis Crick and Sydney Brenner, together with two Cambridge colleagues, published an article in Nature that used simple genetic experiments to ...
Sep 18, 2017 · Protein synthesis and the sequence hypothesis. Crick had been thinking at a very high level about the relation between DNA, RNA, and protein for several years, partly inspired by documents and letters that were exchanged between members of the 20-strong RNA Tie Club, a loose discussion group that included Brenner, Jim Watson, and a host of physicists and mathematicians, led by George Gamow [].
- Matthew Cobb
- 2017
Dec 1, 2016 · Francis Harry Compton Crick was born 100 years ago. He was an inspiring man whose scientific strategy was golden in its success (Olby, 2009). He was remarkable, not only because of what he discovered but for how he set about discovery. According to his own account (Crick, 1988) as a little boy he was already searching for big problems in biology.
- Peter A. Lawrence
- 2016
Mar 9, 2007 · In their landmark 1961 Nature paper entitled “General Nature of the Genetic Code for Proteins,” Francis Crick, Leslie Barnett, Sydney Brenner, and Richard Watts-Tobin (Crick et al., 1961) finally solved the riddle. They concluded correctly that the genetic code is a triplet code, the code is degenerate, triplets are not overlapping, there are no commas (although introns were subsequently ...
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In this paper Crick, Brenner, and their collaborators described a very elegant series of genetic experiments by which they proved that the genetic code for protein was a triplet code. They used an acridine dye, proflavin, to induce mutations in a specific, well-studied gene of a virus, a so-called bacteriophage, that attacked the bacterium Escherichia coli.
