Search results
semanticscholar.org
- Activation of initiation of DNA replication occurs at only a subset of replication origins that were previously assembled in the G1 phase of the cell cycle. This is achieved through a highly regulated sequential two-step process: origin licensing in the G1 phase and origin activation during the S phase.
People also ask
What controls the activation of DNA replication origins?
Why do eukaryotic cells control the activation of DNA replication origins?
How does initiation of DNA replication occur?
How is DNA replication timing regulated?
Why do eukaryotes have a tight control of replication initiation?
How are DNA replication origins selected during the cell cycle?
May 22, 2015 · The activation of DNA replication origins is developmentally controlled. Specific checkpoints regulate the initiation of DNA replication in response to replication stress.
- Eukaryotic DNA replication origins: many choices for ... - Nature
Replication stress and checkpoint controls can regulate the...
- H4S47 O-GlcNAcylation regulates the activation of ... - Nature
We propose that H4S47 O-GlcNAcylation directs origin...
- Eukaryotic DNA replication origins: many choices for ... - Nature
Sep 23, 2010 · Replication stress and checkpoint controls can regulate the use of flexible origins and the activation of dormant origins and can repress late replication origins. Transcriptional features and...
- Marcel Méchali
- 2010
DNA replication is a fundamental process of every organism to duplicate the genome and provide an identical set of chromosomes to the two emerging daughter cells. This process is initiated at specialized DNA regions named origins of replication.
Jan 29, 2019 · In eukaryotes, DNA replication initiates at many sites within the genome (replication origins) in parallel to allow fast duplication of large genomes. This brings about a need for tight control of initiation in order to ensure that each part of the genome is replicated exactly once per cell cycle.
- Karl-Uwe Reusswig, Boris Pfander
- 10.3390/genes10020099
- 2019
- Genes (Basel). 2019 Feb; 10(2): 99.
Abstract. Genomic DNA is replicated every cell cycle by the programmed activation of replication origins at specific times and chromosomal locations. The factors that define the locations of replication origins and their typical activation times in eukaryotic cells are poorly understood. Previous studies highlighted the role of activating ...
Although the ability to initiate DNA replication can partially be conferred by the primary DNA sequence, most replication origins exhibit flexible initiation, as their activation in a fraction of cells is affected by the chromatin environment and by interactions with distal DNA elements.
May 18, 2023 · We propose that H4S47 O-GlcNAcylation directs origin activation through facilitating MCM phosphorylation, and this may shed light on the control of replication efficiency by chromatin...
