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  1. General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease ...

  2. Oct 3, 2012 · Among the exciting causes listed by William Julius Mickle in his extensive 1880 study General Paralysis of the Insane were excessive mental labour, heavy physical work, emotional strain, alcohol and sexual excess.

  3. Jun 1, 2018 · General paresis (or paralysis) of the insane (GPI) was crippling and terminal. It ended in loss of control over mind and body, often accompanied by grandiose delusions of wealth and power and, finally, paralytic death.

    • Kelley Swain
    • 2018
  4. Nov 7, 2015 · General paresis, also known as general paralysis, is a neuropsychiatric disorder of the brain that is caused by late-stage syphilis and has been much ignored by historians, despite its prevalence amongst the male population of the Victorian era.

  5. It was 1912 and Abraham Raphael had general paralysis of the insane (GPI). Abraham Raphael's case notes are recorded in the male casebook held in the Bethlem Royal Hospital archive.

    • Keir Waddington, Rhys Huw Thomas, Martin Willis
    • 2009
  6. ‘General Paralysis of the Insane’.6 General Paralysis of the Insane (GPI) was noted for its sudden appearance in mostly men in mid-life with few pre-existing symptoms, implicating alcohol, heredity, and other environmental factors as primary causes. It was characterised by ‘grandiose

  7. In the early nineteenth century general paresis of the insane (GPI), also known as general paralysis or dementia paralytica, was described as a new psychiatric disorder. It soon became one of the most dreaded mental disorders. Large numbers of patients with GPI were admitted to mental hospitals in the nineteenth and early twentieth century.

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