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Is Sams a symptom of a statin-intolerant patient?
What are statin-associated muscle symptoms (Sams)?
Can statins cause Sams?
Can statins increase musculoskeletal symptoms?
Should statin therapy be continued If a patient has Sams?
Sep 10, 2022 · Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance and are associated with increased risk of cardiovascular events that manifest from statin underutilization and discontinuation.
Jun 19, 2017 · Statins have been associated with a nocebo effect, whereby patients experience adverse effects based on the expectation of harm from a treatment. 5 For muscle-related adverse effects: - Incidence of statin-associated myalgia is lower in blinded RCTs (1% to 5%) 6 compared to observational studies (7% to 29%). 4
Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance. The prevalence of SAMS is estimated to be about 10% (range 5% to 25%), but more than 80% of cases are not caused by the statin.
May 3, 2017 · Statin intolerance due to statin-associated muscle symptoms (SAMS) is low in randomized controlled trials (RCTs), but much higher in clinical observation studies. Statin nonadherence is associated with higher rates of cardiovascular events, and is most frequently attributed to SAMS.
Sep 27, 2017 · Statin-related adverse events (AEs), especially the statin-associated muscle symptoms (SAMS), are the most common reasons for their discontinuation. Therefore, it is important to determine the risk of SAMS in the older population.
- Zhen Zhou, Loai Albarqouni, Monique Breslin, Andrea J Curtis, Mark Nelson
- 2017
ABSTRACT: Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance and are associated with increased risk of cardiovascular events that manifest from statin underutilization
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence and/or discontinuation, contributing to adverse cardiovascular outcomes.
