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OriC
- Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts.
www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02819/fullWhere and When Bacterial Chromosome Replication Starts: A ...
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Most bacterial chromosomes are circular and contain a single origin of chromosomal replication (oriC). Bacterial oriC regions are surprisingly diverse in size (ranging from 250 bp to 2 kbp), sequence, and organization; [39] [40] nonetheless, their ability to drive replication onset typically depends on sequence-specific readout of consensus DNA ...
Apr 21, 2024 · In bacteria, the initiation of replication occurs at the origin of replication, where supercoiled DNA is unwound by DNA gyrase, made single-stranded by helicase, and bound by single-stranded binding protein to maintain its single-stranded state.
Sep 12, 2019 · Origins in bacteria are either continuous or bipartite and contain three functional elements that control origin activity: conserved DNA repeats that are specifically recognized by DnaA (called DnaA-boxes), an AT-rich DNA unwinding element (DUE), and binding sites for proteins that help regulate replication initiation (for reviews, see ; Fig 2A).
- Babatunde Ekundayo, Franziska Bleichert
- 2019
Nov 25, 2018 · Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time.
The initiation of replication occurs at specific nucleotide sequence called the origin of replication, where various proteins bind to begin the replication process. E. coli has a single origin of replication (as do most prokaryotes), called oriC , on its one chromosome.
May 1, 2007 · This Review presents an overview of both the mechanism and regulation of bacterial DNA replication initiation, with emphasis on the features that are similar in eukaryotic and archaeal...
Bacterial replication origins carry DNA sequence motifs recognized by DnaA and other proteins, and an AT-rich region named the DNA unwinding element (DUE). Among bacteria however, the presence, relative arrangement, and position of these DNA motifs are not conserved.
