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    • Generally safe

      • Both Frontline Gold and Frontline Plus are generally safe for use on dogs, but it's important to follow the manufacturer's instructions carefully and consult with your veterinarian if you have any concerns about using these products on your pet.
      vetexplainspets.com/frontline-gold-vs-frontline-plus-for-dogs/
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  2. Both Frontline Gold and Frontline Plus are generally safe for use on dogs, but it’s important to follow the manufacturer’s instructions carefully and consult with your veterinarian if you have any concerns about using these products on your pet.

  3. While both Frontline Plus and Frontline Gold are generally safe for most pets, there is always a risk of sensitivity or allergic reactions. It’s important to monitor your pet closely after applying the medication and consult with your veterinarian if you notice any unusual symptoms.

  4. 1. Are Frontline Gold and Frontline Plus safe for my pet? Both Frontline Gold and Frontline Plus have been extensively tested for safety and are approved for use on dogs and cats. 2. Will my pet have any adverse reactions to Frontline Gold or Frontline Plus?

  5. Frontline flea and tick protection for dogs is one of the most popular topical drugs used by pet parents to help keep their dogs pest free. But many owners—and veterinarians—have voiced concerns about the safety of Frontline’s products.

    • Sara Seitz
    • Typical Frontline Plus Cases and The Impacts
    • The Controversy
    • Background on Frontline
    • Frontline Side Effects
    • Research by The Environmental Protection Agency
    • How Frontline Works
    • A Safety Review
    • Holistic Vets Disagree That Frontline Is Safe

    A five-year old Golden Retriever is brought to the veterinarian with ear and eye discharge three weeks after receiving a dose of Frontline Plus. The symptoms go away within a month. When the dose of Frontline is repeated, the dog develops an ear infection that improves after about six months, but never goes away. The dog dies from liver cancer two ...

    Despite the cases that are well known, some conventional vets disagree with concerns over the safety of Frontline. “There is no evidence to suggest that Frontline causes cancer or other serious diseases,” says Dr Deborah Lichtenberg, a vet from Massachusetts. With regard to allergic reactions, “most of these reactions are mild and don’t require tre...

    The main active ingredient in Frontline Plus, fipronil, was developed between 1985 and 1987 by Rhone Paulenc AG as a broad-use insecticide. It was introduced into the market in 1993. Since then, it has been integrated into a wide variety of products including “pesticide products, granular products for grass, gel baits, spot-on pet care products, li...

    There are many concerns about possible side effects, the most common being skin reactions like hair loss, itching, and redness, and neurological issues like uncoordinated movement and lethargy. However, these side effects are not addressed anywhere on the US website for Frontline. The New Zealand and United Kingdom websites do address safety concer...

    The EPA’s Pesticide Division has found that fipronil enters the body and into the fat, organs, urine and feces of dogs. Research by the EPAin 2009 examined incident data for spot-on pesticides used on dogs, including fipronil products for dogs and cats. The report on Frontline Plus for Dogs shows that of a total of 2469 incidents, they classified: ...

    Of the Frontline Plus ingredients, fipronil is the most dangerous. Fipronil acts by disrupting the central nervous system (CNS), which contains the brain and the spinal cord. It also blocks a receptor, GABA, which has a similar form in mammals, and a receptor called GluCl, which doesn’t exist in humans. Fipronil inhibits the insect GABA receptor mu...

    A review of Frontline Plus side effects and the safety literature on fipronil was done on behalf of the Australian Pesticides and Veterinary Medicines Authority (APVMA). The review said that despite the increased toxicity of fipronil-sulfone, it’s unlikely there would be any adverse effects because there is a rate of passage of less than 5% fiproni...

    Dr Chambreau, Dr Jennifer Ramelmeier and many other holistic veterinarians are critical of studies like the ones in the APVMA review. These studies only look at immediately visible symptoms and fail to account for long-term effects that are often harder to see. These vets provide clients with recommendations on flea and tick prevention without Fron...

  6. Frontline Plus and Frontline Gold are both topical treatments which have proven efficacy for killing fleas, ticks, and chewing lice. Both should be applied once a month, and are safe for dogs over 8 weeks old (so long as they weigh more than three pounds).

  7. FRONTLINE Gold for Dogs is generally considered acceptable for use in most dog breeds. However, individual dogs may have different sensitivities or reactions to medications, including flea and tick control products.

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