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2015.igem.org
- Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency.
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Jan 16, 2023 · Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by...
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Oct 29, 2019 · CRISPR-Cas9 appears to be superseding ZFNs and TALENS as gene editing technology of choice for many scientists and has a high potential to trigger ground-breaking innovations not only in biology...
- Sabina Semiz, Sabina Semiz, Philip C. Aka
- 2019
Mar 24, 2022 · Personalized or precision medicine combines genetic information with phenotypic and environmental characteristics to produce healthcare tailored to the individual and eliminates the constraints of “one-size-fits-all” therapy. Precision medicine is now possible thanks to cancer genome sequencing.
Dec 2, 2019 · The use of CRISPR-cas9 to construct cell or animal models has greatly facilitated cancer research. CRISPR-cas9-based screening accelerates the identification of new drug targets and biomarkers, which will promote the discovery and development of precise cancer treatments.
- Hui Xing, Ling-hua Meng
- 10.1038/s41401-019-0322-9
- 2020
- Acta Pharmacol Sin. 2020 May; 41(5): 583-587.
Dec 2, 2019 · In this review, we describe the progress of CRISPR-cas9-based unbiased screening in precision medicine including identification of new drug targets, biomarkers and elucidation of mechanisms...
- Hui Xing, Ling-hua Meng
- 2020
Oct 15, 2023 · CRISPR/Cas9 nuclease achieves gene editing by a programmable single-guide RNA (sgRNA), which is a fusion of trans-activating RNA (tracrRNA) and CRISPR-targeting RNA (crRNA), to guide the Cas9 protein to the target DNA.
Nov 8, 2023 · We will discuss CRISPR/Cas9-based diagnostics and therapeutic approaches. Finally, we will address future perspectives on CRISPR/Cas9 genome editing and the expansion of genome editors’ toolboxes with Cas9 orthologs, other CRISPR/Cas proteins, and recently described Fanzor enzymes.
