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- Angiotensin receptor-neprilysin inhibitors (ARNIs) are a new class of cardiovascular agents characterized by their dual action on the major regulators of the cardiovascular system, including the renin–angiotensin system (RAS) and the natriuretic peptide (NP) system.
www.nature.com/articles/s41440-021-00706-1Angiotensin receptor-neprilysin inhibitors: Comprehensive ...
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Aug 20, 2021 · The promising roles of ARNI in cardiovascular diseases. ARNI (e.g., sacubitril/valsartan) inhibits neprilysin (NEP) and the binding of angiotensin II to its receptor (AT1R), preventing the activation of intracellular signaling cascades.
- Table 1
The renin-angiotensin-aldosterone system (RAAS) plays a...
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The renin-angiotensin-aldosterone system (RAAS) plays a...
- PMC Free Article
Indeed, a new class of drug, the angiotensin...
- Table 1
Jul 21, 2021 · Angiotensin receptor-neprilysin inhibitors (ARNIs) are a new class of cardiovascular agents characterized by their dual action on the major regulators of the cardiovascular system,...
- Koichi Yamamoto, Hiromi Rakugi
- 2021
Nov 10, 2021 · The angiotensin receptor–neprilysin inhibitor sacubitril–valsartan simultaneously blocks the renin–angiotensin system and inhibits the breakdown of several vasoactive peptides. 7 In...
- Marc A. Pfeffer, Brian Claggett, Eldrin F. Lewis, Christopher B. Granger, Lars Køber, Aldo P. Maggio...
- 2021
Apr 17, 2023 · ARNI has demonstrated superior cardioprotective effects compared with renin–angiotensin system inhibitors (RAS‐Is) in large clinical trials such as the PARADIGM‐HF (Prospective Comparison of ARNI With ACEI [Angiotensin‐Converting Enzyme Inhibitor] to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial.
Jul 10, 2023 · A systematic review and meta-analysis found that compared with the renin–angiotensin–aldosterone system inhibitor, patients treated with ARNI had lower incidence of composite renal impairment, ESRD, drug discontinuation due to renal events, severe hyperkalemia and a slower eGFR decline . A randomized, double-blind trial compared the renal ...
- Xiaobo Wang
Mar 24, 2020 · Recent large scale randomized clinical trials (RCTs) have provided compelling evidence that sacubitril-valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is superior to an ACEI in reducing mortality and HF hospitalization and in improving quality of life in patients with stage C HFrEF.
Apr 28, 2019 · Indeed, a new class of drug, the angiotensin receptor–neprilysin inhibitors (ARNi), has the ability to counteract the effects of angiotensin II as well as to increase the activity of NPs. ARNi have already been proven to be effective in the treatment of heart failure with reduced ejection fraction.