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Role: Founder and CEO. Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
- About Joe Cohen: How SelfDecode's Founder Biohacked His Way ...
Joe Cohen is the founder and CEO of SelfDecode. Joe suffered...
- Joe Cohen - Founder and CEO of SelfDecode - SelfDecode Resources
Role: Founder and CEO. Articles by Joe Cohen, BS. Joe is a...
- About Joe Cohen: How SelfDecode's Founder Biohacked His Way ...
Role: Founder and CEO. Articles by Joe Cohen, BS. Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
Mar 11, 2022 · Joe Cohen is the founder and CEO of SelfDecode. Joe suffered from many health issues growing up, but, by taking a personalized approach to his health, he was able to find the strategies that worked best for his body. Read on to learn more about Joe Cohen!
Biohacker and SelfDecode founder Joe Cohen is not afraid to step on people’s toes. Join him each week as he shares his 15+ years of experience in biohacking ...
- The First Version of SelfDecode
- Rebuilding SelfDecode from The GroundUp: Polygenic Risk Scoring
- Predictive Power with Individual Or A Handful of Variants
- How Do Polygenic Risk Scores Compare to Standard Methods?
- Good Tech Is Not Cheap
- Polygenic Risk Scores Are Not Absolute
- Other Companies Introducing Polygenic Risk Scores
- When Are Individual Variants Useful to Look at?
- Importance of Ancestry Adjusted Polygenic Risk Scoring
SelfDecode was first released in 2016 as the first step to understanding your genetics. It was an easy way to look at your genetic variants (SNPs) and find the different peer-reviewed studies attached to those SNPs. But, there was still a lot of manual labor that needed to be done on the user side. Plus, we didn’t want people to mainly look at indi...
In 2018, studies started to come out demonstrating that even a few hundred SNPs were not enough to give an accurate prediction score for complex traits. Often, thousands or even millions of variants were impacting a complex trait like mood or cardiovascular disease. These variants were having small but cumulative impacts, so it was really important...
For any given topic, there are multiple studies published, and typically there’s no overlap in the SNPs that are significantly associated with a trait. If you read up a lot in the area, you’ll see that studies usually can’t be replicated, and the impact for a given SNP is usually very small. The only way to get around this is through cutting-edge P...
One of the first things we set out to test was how much better the new methods were than the old methods. Using public data sets, we gathered the data of 800,000 people that included their genetic information, along with their likelihood of getting various conditions or traits. This allowed us to test the predictiveness of different methods. We loo...
When we initially released these pipelines for polygenic risk scoring, it was costing us around $25 per user to analyze the results. This compared to less than one cent before. We put in a lot of effort to reduce the cost, but it still costs quite a lot to run these systems, even on a marginal basis. Our bet is that consumers will choose quality ov...
Keep in mind, however, that polygenic scores do notprovide an absolute risk for a disease. For example, consider two people with high polygenic risk scores for having coronary heart disease. The first person is 22 years old, while the other is 98. Even if they have the same polygenic risk score or genetic predisposition, they will have very differe...
We realized that there was a big problem of quality in the personalized health industry that stemmed from a lack of ready technology that can be offered at scale. So we decided to start a business unit under our parent company called OmicsEdge that licenses these technologies and reports to other companies, so that we can increase the quality of an...
Sometimes, when forming a hypothesis about which recommendations can work better for you, it can help to look at individual or a group of variants. I typically look at individual variants when I am looking at clues for a mechanism increasing my risk. For example, it was important to see that my tryptophan hydroxylase genewas not very effective at c...
According to the NIH, 78% of genomic studies are done on Europeans . This is an important issue because when you’re dealing with a US audience, which is diverse, Polygenic Risk Score should take into account the ancestry in order to get the best results, and adjust the scores accordingly . This is one of the issues preventing Polygenic Risk Scoring...
Role: Founder and CEO. Articles by Joe Cohen, BS. Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
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SelfDecode's founder Joe Cohen talks about his chronic health issues growing up and why he created SelfDecode. Joe suffered from fatigue, brain fog, insomnia...
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- The Joe Cohen Show
