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Zonisamide (brand name: Zonegran®) is an anticonvulsant (antiseizure) medication that is used either as an initial therapy for epilepsy or as an add-on drug for seizures that are difficult to control. Its use in cats and dogs to treat seizures is “off label” or “extra label”. Many drugs are commonly prescribed for off-label use in ...
Aug 27, 2024 · Zonisamide offers the possibility of more freedom and improved mobility, as the dog no longer needs to live in constant fear of sudden seizures. 5. Enhanced Bond with Owners: A dog’s frequent seizures can be emotionally distressing for both the pet and its owners.
Jan 8, 2022 · An alternative anticonvulsant option with few side effects is zonisamide. Zonisamide is an anticonvulsant medication unrelated to other anticonvulsants routinely used for treating dogs and cats. Zonisamide can be used alone or in combination with phenobarbital and/or potassium bromide. This is useful when your pet's seizures are inadequately ...
- Lorie Huston
Sep 15, 2020 · Zonisamide for dogs may cause the following side effects: Sedation or drowsiness. Nausea. Vomiting. Loss of appetite. Incoordination. Rarely, the medication may also cause liver damage, so monitor your pet for yellowing of the skin, gums, or the whites of the eyes. Report any side effects to your vet.
Oct 2, 2023 · Typically, zonisamide works best when given every 12 hours. But sometimes once-a-day dosing can also effectively treat seizures. Your dog can take the zonisamide with or without food—whichever is best for him or her. Caution: Do not stop giving zonisamide without talking to your vet. Rapidly stopping the zonisamide can lead to rebound seizures.
Zonisamide is used as an anticonvulsant in dogs and cats. Based on the author’s clinical experience, zonisamide may be effective when used as monotherapy or in conjunction with other anticonvulsants (eg, phenobarbital, potassium bromide, levetiracetam). In some cases, zonisamide may reduce seizure frequency by up to 70% to 80%. 1,2.
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Multiple studies have evaluated the addition of a newer generation AED (ie, pregabalin, levetiracetam, zonisamide) to phenobarbital ± bromide therapy, resulting in at least a 50% reduction in seizure frequency. 21-23 However, placebo has been shown to reduce the number of seizures in dogs 79% of the time, and also reduces seizure frequency by 50% in 29% of patients. 24 One explanation for the ...
