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Biological assay
- Biological activity is “the capacity of a specific molecular entity to achieve a defined biological effect” on a target (Jackson et al., 2007), and it is measured by the activity or concentration of a molecule required to cause that activity, and biological activity is always measured by biological assay.
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Mar 16, 2007 · The biological activity of a molecular entity is defined as A = cf, where A is the activity, c the amount-of-substance concentration, and f is a parameter designated as “inherent activity.” Units and dimensions are determined by the type of activity, catalytic (katal) or binding (mol −1 L).
- Craig M. Jackson, M. Peter Esnouf, Donald J. Winzor, David L. Duewer
- 2007
Jan 1, 2022 · Biological activity is the ability of a particular molecular entity to bring about a specific biological change on the target whose biological effect is to be effected. The effectiveness and concentration of the biological activity needed to impact the effect is measured in several ways.
Biological activity is usually measured by a bioassay and the activity is generally dosage -dependent, which is investigated via dose-response curves. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses.
Jun 8, 2007 · The biological activity of a molecular entity is defined as A=cf, where A is the activity, c the amount-of-substance concentration, and f is a parameter designated as “inherent activity.”...
Jan 1, 2022 · Biological activity always depends on the dose given to the living organism, so it is logical to show either beneficial or adverse effects that range from low to high. Absorption, distribution, metabolism, and excretion are the main action used to measure biological activity.
biological activity. The definition is intended first to pro-vide a framework for communicating, discussing, and expanding knowledge of biological activity as it relates to chemical structure. A second goal is to separate the mea-surement of the structure-derived biological properties from that of the structure, physical properties, and amounts
Jun 20, 2019 · Biological activity, usually but not always reported in units, can be derived through comparison with a specific reference preparation for that molecule to derive a relative activity rather than an absolute unit.
