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Richter's syndrome means that the CLL changes (transforms) into a type of lymphoma. It usually transforms into a type of non-Hodgkin lymphoma (NHL). This is called diffuse large B cell lymphoma. Rarely, CLL can transform into Hodgkin lymphoma or other types of non-Hodgkin lymphoma. This transformation can happen quickly, and you might become ...
organisms that have been labelled with an antibody by the B-cells, as well as cells that have become virally infected or cancerous. 3. NK-cells (natural killer cells) attack cancer cells and viruses. Chronic Lymphocytic Leukaemia (CLL) is a cancer of the B-lymphocyte cells (B-cells). Richter syndrome (RS), also called Richter transformation, is the
- What Is Richter's Syndrome?
- Who Develops Richter's Syndrome?
- Symptoms of Richter's Syndrome
- Risk Factors For Richter's Syndrome
- How Do You Treat Richter's Syndrome?
- What Is The Life Expectancy For Richter's Syndrome?
- Future Research
- Summary
RS develops in someone who already has a cancer of the white blood cells. This initial cancer a person is diagnosed with has two different names, depending on where in the body the cancer is found. Chronic lymphocytic leukemia (CLL) is mostly found in the blood and bone marrow, and small lymphocytic lymphoma (SLL) is found mostly in the lymph nodes...
The development of RS in people with CLL or SLL is relatively uncommon. Estimates are that Richter’s transformation occurs in only about 5% of patients with CLL or SLL. Other sources cite a range between 2% and 10%. If RS does develop, it is very unusual that it would occur at the same time the CLL or SLL is diagnosed. People who develop RS from CL...
If your CLL or SLL has transformed to diffuse large B-cell lymphoma, you will notice a distinct worsening of your symptoms. The characteristics of RS include rapid tumor growth with or without extranodal involvement—that is, new growths may be confined to the lymph nodes, or cancer may involve organs other than the lymph nodes, such as the spleen a...
The risk of developing RS from CLL or SLL is not related to the stage of your cancer, how long you have had it, or the type of response to therapy you have received. In fact, scientists do not fully understand what actually causes the transformation. Older studies have described that some patients whose CLL cells show a specific marker called ZAP-7...
Treatment of RS usually involves chemotherapy protocols that are commonly used for NHL. These regimens have typically produced overall response rates of about 30%. Currently, the treatment of Richter’s transformation with diffuse large B-cell lymphoma consists of combination chemotherapy plus rituximab. Adding ofatumumab—a monoclonal antibody that ...
Unfortunately, the average survival with regular chemotherapy is less than six months after RS transformation. However, new therapies and combinations are continually being tried in clinical trials. As with all lymphomas, survival statistics can be hard to interpret. Individual patients differ in their general health and strength prior to their dia...
To improve survival in patients with RS, scientists need to gain a better understanding of what causes the transformation from CLL to occur. With more information about RS at a cellular level, better-targeted therapies could be developed against those specific abnormalities. Experts caution, however, that since there are a number of complicated mol...
Richter's syndrome is a relatively uncommon transformation of CLL and SLL that occurs in 2-10% of patients with CLL or SLL. Symptoms can include swollen lymph nodes, abdominal pain, low red blood cell count, and low platelet count. Treatment can be difficult, but more research is being done to find effective treatments.
Apr 1, 2024 · Patients who have undergone treatment for chronic lymphocytic leukemia (CLL) may experience Richter transformation, a rare syndrome in which CLL turns into a more aggressive disease. William Wierda, M.D., shares what patients should know about diagnosis and treatment options for Richter transformation.
Richter’s Syndrome (RS), also known as Richter’s Transformation, is a rare complication of Chronic Lymphocytic Leukaemia (CLL) and/or Small Lymphocytic Lymphoma (SLL). Richter’s Syndrome occurs in approximately 2-10% of all CLL/SLL patients during the course of their disease. In the most cases the normally slow growing, or indolent, CLL transforms into a common type of non-Hodgkin ...
Feb 20, 2024 · If Richter’s transformation of CLL occurs, you may experience symptoms known as B symptoms. These typically include: fever. drenching night sweats. rapid unexplained weight loss. If you have CLL ...
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What is Richter's transformation?
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2 days ago · Richter’s Transformation (RT) is usually an aggressive transformation of chronic lymphocytic leukemia into a fast–moving lymphoma, usually clonally related, DLBCL (diffuse large B-cell lymphoma). RT is associated with a very poor response to most therapies and has a discouraging prognosis. It remains one of the most pressing unmet needs in ...
