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There are three common Kidd phenotypes: JK (a+b-), JK (a-b+), and JK (a+b+). The Jk-null phenotype, JK (a-b-), is rare in most populations. Individuals with this blood type are often detected after they have been immunized to Kidd antigens during a previous blood transfusion or pregnancy.
- Laura Dean
- 2005
- 2005
Jka and Jkb are the products of alleles with Asp280 and Asn280 in the fourth external loop of the Kidd glycoprotein. Jka and Jkb have similar prevalences in White and Asian populations but Jka is more common in Black populations than Jkb.
Failing to detect all antibody specificities in a sample can lead to a potentially life-threatening hemolytic transfusion reaction. To minimize this risk, specific antibodies like anti-Jk a, anti-Jk b, anti-S, anti-s, anti-Fy a, and anti-Fy b should be actively excluded.
Jun 7, 2024 · A patient has a negative antibody screen and receives a red blood cell (RBC) transfusion for symptomatic anemia. 2 days later, the patient develops hematuria and is found to have a positive direct antiglobulin test (DAT [IgG and C3]). A screen demonstrates a previously unidentified Jkb antibody.
Antibody Panels •Consist of red cells from eight or more group O donors •For commonly encountered clinically significant alloantibodies: 2 antigen pos and 2 antigen neg cells •1 x R1R1 (CCDDee) and 1 x R1wR1 (CwCDDee) •Between them, these two cells should express the antigens K, k, Fya, Fyb, Jka, Jkb, S, s
Jk (a−b−) red cells do not express Jk3. The antigens are encoded by SLC14A1 gene on chromosome 18. JK*01 allele differs from JK*02 at nt 838 (G/A) and in the protein, at amino acid 280, Jk a expression is associated with aspartate and asparagine is associated with Jk b.
People also ask
Can JKA and -JKB be detected on adsorption/elution test?
How is jk3 phenotype detected?
Are anti-Jka and -Jkb antibodies common?
Why are JK antigens important in transfusion medicine?
The commonly mentioned naturally occurring antibodies belong to the ABO, Hh, Ii, Lewis, MN, P blood group systems. Anti-Kidd antibodies are notorious for confounding features and as a causal for delayed hemolytic transfusion reactions.
