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- The spindle consists of microtubules, polar dynamic fibers that polymerize from tubulin subunits, as well as hundreds of other proteins that function together to orchestrate chromosome segregation. These include a large set of microtubule-based motor proteins that use ATP hydrolysis to generate movement, or alter microtubule dynamics.
www.sciencedirect.com/science/article/pii/S0960982204006979Mechanisms and Molecules of the Mitotic Spindle - ScienceDirect
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Sep 21, 2004 · The spindle consists of microtubules, polar dynamic fibers that polymerize from tubulin subunits, as well as hundreds of other proteins that function together to orchestrate chromosome segregation. These include a large set of microtubule-based motor proteins that use ATP hydrolysis to generate movement, or alter microtubule dynamics.
- Sharat Gadde, Rebecca Heald
- 2004
Jan 25, 2021 · The life of a spindle starts with its formation by interactions between microtubules and chromosomes mediated by the microtubule-associated proteins and the kinetochore proteins during prometaphase and ends with chromosome segregation in anaphase, followed by spindle disassembly in telophase.
- Nenad Pavin, Iva M. Tolić
- 2021
Feb 8, 2017 · Three pathways drive the nucleation of microtubules to form a common mitotic spindle: the centrosome-, chromatin- and microtubule-mediated microtubule nucleation pathways.
- Suzanna L. Prosser, Laurence Pelletier, Laurence Pelletier
- 2017
The mitotic spindle is made of up to hundreds of thousands of microtubules (MTs) and roughly 1,000 MT-associated proteins (MAPs), of which ~200 are essential (22–25). Spindle MAPs can be grouped into several activity classes, namely MT nucleation, MT dynamics, MT transport, and MT cross-linking.
Jun 6, 2017 · During eukaryotic cell division, the mitotic spindle mediates the separation of chromosomes into the two daughter cells (Gadde and Heald, 2004; Kapoor, 2017). Microtubules within the spindle are organized in a dense array, with their positions, orientations, lengths, regions of overlap, and nucleation sites regulated by motor and nonmotor proteins.
- Scott Forth, Tarun M. Kapoor
- 10.1083/jcb.201612064
- 2017
- J Cell Biol. 2017 Jun 5; 216(6): 1525-1531.
Jun 15, 2012 · A large number of factors are involved in mechanisms that favor MT stabilization or destabilization. This allows the cell to alter the parameters of MT dynamics and to reorganize its MT network. This occurs, for example, during cell division, when MTs form the mitotic spindle.
Feb 2, 2021 · The mitotic spindle is a marvelous microtubule-based micromachine that segregates the genome from one cell into two equal parts destined to the future daughter cells (McIntosh, 2016). Spindle microtubules can be divided into three main classes according to their localization and function: kinetochore microtubules that bind the kinetochore, a ...
