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      • Many multicellular organisms, including humans, carry microbial communities on, or have microbial communities associated with, their epithelial surfaces. An organism’s microbiota, with its capacity to protect against infection, provide nutrients, promote immune development, and even influence cognition (1), can be critical for healthy functioning.
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  2. Mar 1, 2015 · In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans.

  3. Apr 1, 2002 · Bacterial pathogens express a wide range of molecules that bind host cell targets to facilitate a variety of different host responses. The molecular strategies used by bacteria to interact with the host can be unique to specific pathogens or conserved across several different species.

  4. Apr 21, 2024 · Some bacteria produce virulence factors that promote infection by exploiting molecules naturally produced by the host. For example, most strains of Staphylococcus aureus produce the exoenzyme coagulase, which exploits the natural mechanism of blood clotting to evade the immune system.

  5. Dec 11, 2019 · A comprehensive understanding of host–pathogen interaction will provide new insights into the identification of novel targets for both host effectors and microbial factors and will lead to...

    • Eun-Kyeong Jo
    • hayoungj@cnu.ac.kr
    • 2019
  6. The many potential benefits of a microbiome—the microbiota plus associated host factors—can foster the view that humans harbor an intrinsically helpful ecosystem in their gut that is regulated primarily by diet.

  7. May 13, 2021 · Microbes can play both pathogenic and commensal roles, and it is common to label them as either detrimental or beneficial. However, the lines between good and bad can be blurred. This graphical summary attempts to illustrate the complexity of host-microbe interactions, with outcomes for human health being highly context specific.

  8. Sep 14, 2017 · Nature Communications - Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from...

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