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1. www.ncbi.nlm.nih.gov › pmc › articlesBacterial Protein Synthesis as a Target for Antibiotic Inhibition

   www.ncbi.nlm.nih.gov › pmc › articles

   Protein synthesis in bacteria can be divided into four main steps: initiation, elongation, termination, and ribosome recycling. Two of these steps—initiation and elongation—are targeted by numerous antibiotics.

   • From Targets to Networks

     Erythromycin, carbomycin, and spiramycin inhibit protein...

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     Pharmacology – ANTIBIOTICS – DNA, RNA, FOLIC ACID, PROTEIN SYNTHESIS INHIBITORS (MADE EASY)

     3 May 2018

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     Protein Synthesis Inhibitors | Antibiotics & Mechanism

     24 Aug 2013

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     Protein Synthesis Inhibitors antibiotics animation video

     29 Dec 2017

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3. microbenotes.com › protein-synthesis-inhibitorsProtein Synthesis Inhibitors- Definition, Examples ...

   microbenotes.com › protein-synthesis-inhibitors

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   Aug 3, 2023 · Some antibacterial classes inhibit bacterial protein synthesis by interfering with the 30s or 50s subunit. Antibiotics target three different steps which include initiation, formation of the 70s, and elongation process of making polypeptides.

4. bio.libretexts.org › Bookshelves › Microbiology13.2D: Inhibiting Protein Synthesis - Biology LibreTexts

   bio.libretexts.org › Bookshelves › Microbiology

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   Dec 24, 2022 · In general, protein synthesis inhibitors work at different stages of prokaryotic mRNA translation into proteins like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and ribosomal translocation), and termination. The following is a list of common antibacterial drugs and the stages which they target.

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6. www.nature.com › articles › nrmicro2333How antibiotics kill bacteria: from targets to networks - Nature

   www.nature.com › articles › nrmicro2333

   May 4, 2010 · Bactericidal antibiotics target a diverse set of biomolecules for inhibition to achieve cell death, including DNA topoisomerases (involved in modulating DNA topology), RNA polymerase (involved in...

   • Author: Michael A. Kohanski, Daniel J. Dwyer, James J. Collins, James J. Collins, James J. Collins

   • Publish Year: 2010

7. www.ncbi.nlm.nih.gov › pmc › articlesHow antibiotics kill bacteria: from targets to networks - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother. 1982; 21 :811–8.

   • Author: Michael A. Kohanski, Daniel J. Dwyer, James J. Collins, James J. Collins, James J. Collins
   • DOI: 10.1038/nrmicro2333

   • Publish Year: 2010
   • Published: 2010/06

8. www.nature.com › articles › s41579/020/00443-1Proximate and ultimate causes of the bactericidal ... - Nature

   www.nature.com › articles › s41579/020/00443-1

   Oct 6, 2020 · The two drugs inhibit two sequential steps in tetrahydrofolate synthesis (required for nucleotide synthesis), but this cannot explain the bactericidal synergism.

9. People also ask

   How do protein synthesis inhibitors work?

   • Protein synthesis inhibitors usually act at the ribosomal level in the translation process of protein synthesis that includes initiation, elongation, and termination. In both prokaryotes and eukaryotes, ribosomes are the main site for protein synthesis.

   Protein Synthesis Inhibitors- Definition, Examples, Inhibition, Resistance

   microbenotes.com/protein-synthesis-inhibitors/

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   How does protein synthesis occur in bacterial cells?

   • Protein synthesis is coupled to growth phases of bacterial cells. During the exponentially growing phase, most ribosomes are actively engaged in protein synthesis. When the nutrient source is limited, bacterial cells enter into the stationary phase where 70S ribosomes are dimerized into inactive 100S dimers .

   Bacterial protein synthesis - ScienceDirect

   www.sciencedirect.com/science/article/pii/B9780128186190001349

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   Which antibiotic inhibits bacterial protein synthesis?

   • Antibiotics that inhibit or interferes with bacterial protein synthesis include; Aminoglycosides, Macrolides, Tetracycline, Oxazolidinone, and Chloramphenicol. Protein synthesis inhibitors. Created with BioRender.com Aminoglycosides: They consist of different amino acids with different functions and are hydrophilic sugars.

   Protein Synthesis Inhibitors- Definition, Examples, Inhibition, Resistance

   microbenotes.com/protein-synthesis-inhibitors/

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   Is initiation of protein synthesis a target for antimicrobials?

   • Initiation of protein synthesis: A target for antimicrobials. Expert Opin Ther Targets 12: 519–534. [ PubMed] [ Google Scholar] Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. 2013. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci 110: 20994–20999.

   Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5008061/

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10. www.sciencedirect.com › science › articleBacterial protein synthesis - ScienceDirect

    www.sciencedirect.com › science › article

    Jan 1, 2024 · protein synthesis inhibitor. antibiotic. tRNA. mRNA. decoding. peptidyl transfer. translation initiation. 13.1. Ribosome and protein translation. Ribosomes are sophisticated ribonucleoprotein machines catalyzing protein biosynthesis in all living cells.