Search results
Protein synthesis in bacteria can be divided into four main steps: initiation, elongation, termination, and ribosome recycling. Two of these steps—initiation and elongation—are targeted by numerous antibiotics.
- From Targets to Networks
Erythromycin, carbomycin, and spiramycin inhibit protein...
- From Targets to Networks
Aug 3, 2023 · Some antibacterial classes inhibit bacterial protein synthesis by interfering with the 30s or 50s subunit. Antibiotics target three different steps which include initiation, formation of the 70s, and elongation process of making polypeptides.
Dec 24, 2022 · In general, protein synthesis inhibitors work at different stages of prokaryotic mRNA translation into proteins like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and ribosomal translocation), and termination. The following is a list of common antibacterial drugs and the stages which they target.
May 4, 2010 · Bactericidal antibiotics target a diverse set of biomolecules for inhibition to achieve cell death, including DNA topoisomerases (involved in modulating DNA topology), RNA polymerase (involved in...
- Michael A. Kohanski, Daniel J. Dwyer, James J. Collins, James J. Collins, James J. Collins
- 2010
Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother. 1982; 21 :811–8.
- Michael A. Kohanski, Daniel J. Dwyer, James J. Collins, James J. Collins, James J. Collins
- 10.1038/nrmicro2333
- 2010
- 2010/06
Oct 6, 2020 · The two drugs inhibit two sequential steps in tetrahydrofolate synthesis (required for nucleotide synthesis), but this cannot explain the bactericidal synergism.
People also ask
How do protein synthesis inhibitors work?
How does protein synthesis occur in bacterial cells?
Which antibiotic inhibits bacterial protein synthesis?
Is initiation of protein synthesis a target for antimicrobials?
Jan 1, 2024 · protein synthesis inhibitor. antibiotic. tRNA. mRNA. decoding. peptidyl transfer. translation initiation. 13.1. Ribosome and protein translation. Ribosomes are sophisticated ribonucleoprotein machines catalyzing protein biosynthesis in all living cells.