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- Complementary Mechanisms of Action: Amlodipine and Lisinopril work through different mechanisms to lower blood pressure. Amlodipine primarily acts by blocking calcium channels, while Lisinopril inhibits the production of angiotensin II. By combining these medications, the effects of both mechanisms can be maximized.
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Sep 19, 2024 · Amlodipine and lisinopril are common and effective first-choice medications for managing hypertension. They work to lower blood pressure in different ways and have distinct safety profiles, contraindications, and drug interactions.
Aug 7, 2024 · If one medicine can't lower your blood pressure, your doctor may try combination treatment for hypertension. Studies show that many people get better control of blood pressure with combination ...
Taking Amlodipine and Lisinopril together can offer enhanced blood pressure control and a reduction in cardiovascular events for certain individuals. However, it is crucial to consult with your healthcare provider to determine if this combination therapy is suitable for you.
How does amlodipine work? Amlodipine is a type of medicine called a calcium channel blocker. Like other calcium channel blockers, it relaxes and widens blood vessels.
If you take other medicines that lower blood pressure, such as ramipril or lisinopril, at the same time as amlodipine, the combination can sometimes lower your blood pressure too much. When your blood pressure is low, you may feel dizzy or faint. If this keeps happening to you, tell your doctor as your dose may need to be changed.
Lisinopril inhibits angiotensin converting enzyme (ACE), the enzyme responsible for converting angiotensin I into angiotensin II (a vasoconstrictor). Amlodipine inhibits influx of calcium into smooth muscle cells through calcium channels thereby inhibiting Ca-dependent contraction.
Mar 15, 2020 · Four main classes of medications are used in combination therapy for the treatment of hypertension: thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEIs ...