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- On the one hand was Metchnikoff, a comparative embryologist who was strongly influenced by Charles Darwin (1809–1882) and viewed immunology from an evolutionary standpoint. On the other hand was Ehrlich, obsessed with chemistry, who built his views on the 'lock-and-key' principle.
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How did Metchnikoff distinguish microphages from macrophage?
Jul 1, 2008 · By discovering phagocytes and phagocytosis, Metchnikoff described the principle mechanism of innate immunity, whereas Ehrlich proposed the side-chain theory, thus laying the fundamentals for...
- Élie Metchnikoff (1845–1916): celebrating 100 years of ...
The year 2016 marks 100 years since the death of Élie...
- Élie Metchnikoff (1845–1916): celebrating 100 years of ...
Jun 16, 2016 · Since Metchnikoff’s era, significant contributions from the scientific community have brought considerable knowledge to the immunology arena, shedding a new light on innate and adaptive immunities that have become more complementary and integrated in the host resistance to infectious diseases.
- Fabrice Merien
- 10.3389/fpubh.2016.00125
- 2016
- Front Public Health. 2016; 4: 125.
Abstract. We celebrate the centenary of the Nobel award to Elie Metchnikoff in 2008, shared with Paul Ehrlich, as respective pioneers of cellular and humoral immunology. Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection ...
Aug 1, 2016 · The year 2016 marks 100 years since the death of Élie Metchnikoff (1845–1916), the Russian zoologist who pioneered the study of cellular immunology and who is widely credited with the discovery...
- David M. Underhill, Siamon Gordon, Beat A. Imhof, Gabriel Núñez, Philippe Bousso
- 2016
Using improved staining with aniline dyes, a contribution of Ehrlich, Metchnikoff distinguished microphages (polymorphonuclear leukocytes), from macrophages (motile and fixed), in organs such as the liver (Kupffer cells), spleen, lung (alveolar dust cells), lymph nodes and intestine.
- Siamon Gordon
- 2008
Elie Metchnikoff was not only the first to describe phagocytosis of invading pathogens by specialized blood cells - macrophages and neutrophils - he also was interested in the impact of normal flora on well-being and in pre- and probiotic diet and their influence on the normal flora.
Nov 27, 2008 · Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a broad range of model organisms for microscopic studies in vivo and in vitro .
