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      • In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter.
      pubmed.ncbi.nlm.nih.gov/30655413/

      The importance of synthetic chemistry in the pharmaceutical ...

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  3. www.nature.com › articles › s41570/021/00288-zThe application of modern reactions in large-scale synthesis

    Jun 22, 2021 · As such, the development of new synthetic methods can have major impacts on the pharmaceutical industry, not only by increasing overall efficiency but also by enabling access to novel...

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  4. www.nature.com › articles › s41557/018/0021-zOrganic synthesis provides opportunities to transform drug ...

    Mar 22, 2018 · There is clear evidence that new synthetic methodology published by academics can spark the pharmaceutical industry to make and explore structures that were previously inaccessible.

    • David C. Blakemore, Luis Castro, Ian Churcher, David C. Rees, Andrew W. Thomas, David M. Wilson, Ant...
    • 2018

  5. www.ncbi.nlm.nih.gov › books › NBK92218New Methods in Synthesis and Development for Pharmaceuticals

    Selection of a therapeutic target based on unmet or undermet clinical need is an important early step in drug discovery. Increased use of outcome studies to establish the therapeutic value of new medicines has raised target choice to a new level of sophistication.

    • National Research Council (US)
    • 2004

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  7. www.science.org › doi › 10The importance of synthetic chemistry in the pharmaceutical ...

    Jan 18, 2019 · Of particular interest are new synthetic methods that enable medicinal chemists to control reactivity in complex, drug-like molecules, access non-obvious vectors for SAR development, and rapidly access new chemical space or unique bond formations.

    • Kevin R. Campos, Paul J. Coleman, Juan C. Alvarez, Spencer D. Dreher, Robert M. Garbaccio, Nicholas ...
    • 2019

  8. pubmed.ncbi.nlm.nih.gov › 30655413The importance of synthetic chemistry in the pharmaceutical ...

    Jan 18, 2019 · We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.

    • Kevin R. Campos, Paul J. Coleman, Juan C. Alvarez, Spencer D. Dreher, Robert M. Garbaccio, Nicholas ...
    • 2019

  9. www.nature.com › articles › nrdExpanding the medicinal chemistry synthetic toolbox | Nature ...

    Aug 24, 2018 · More intense crosstalk between synthetic and medicinal chemists in industry and academia should enable enhanced impact of new methodologies in future drug discovery.

  10. www.science.org › doi › pdfThe importance of synthetic chemistry in the pharmaceutical ...

    Indeed, the application of new synthetic methods is rapidly expanding the realm of accessible chemical matter for modulating a broader array of biological tar-gets, and there is a growing recognition that innovations in synthetic chemistry are chang-ing the practice of drug discovery.

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