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- PEA is the only neurotransmitter that crosses the blood brain barrier freely and bidirectionally.
blog.healthmatters.io/2019/04/26/what-is-the-neurotransmitter-pea-high-and-low-values-lab-results-explained/What is the neurotransmitter PEA? High and low values | Lab ...
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Dec 16, 2019 · PEA may trigger neurotransmitters for “brain plasticity” and “neurogenesis” (the forming of new brain cells, information processing connections, and functions) that increase cognition, learning, memory, skills, smartness, and performance.
Mar 5, 2020 · The presence of the labelled PEA in the brain (≈98 ng·mg −1 of brain tissue) demonstrated the ability of the compound to penetrate, although in small amounts, through the blood–brain barrier . Mechanistically, PEA may be a ligand for peroxisome proliferator activated receptor α (PPARα), one of a group of nuclear receptor proteins that ...
- Marika Cordaro, Salvatore Cuzzocrea, Rosalia Crupi
- 10.3390/antiox9030216
- 2020
- Antioxidants (Basel). 2020 Mar; 9(3): 216.
May 18, 2021 · PEA’s ability to target neuro-inflammation, pain, depression, anxiety and at the same time support neurogenesis and synaptic pruning makes it a viable therapeutic aid for brain disorders. The clinical data look promising, but further clinical trials are needed to confirm these findings.
- Paul Clayton, Mariko Hill, Nathasha Bogoda, Silma Subah, Ruchitha Venkatesh
- 2021
May 5, 2022 · In the brain, PEA is produced “on demand” by neurons, microglia, and astrocytes, and thus plays a pleiotropic and pro-homeostatic role, when faced with external stressors provoking inflammation. PEA exerts a local anti-injury function by down-modulating mast cell activation and protecting neurons from excitotoxicity [ 15 , 16 , 17 ].
- 10.3390/biom12050667
- 2022/05
- Biomolecules. 2022 May; 12(5): 667.
Aug 22, 2024 · This remarkable conductor, known as phenylethylamine (PEA), is a natural stimulant that plays a crucial role in our brain’s intricate workings, particularly in its relationship with dopamine, the neurotransmitter often associated with pleasure and reward.
5 days ago · Palmitoylethanolamide (PEA) is an endocannabinoid, which means it is a brain-signaling molecule that activates the cannabinoid receptors which leads to various effects such as pain relief and anti-inflammatory effects.
In a high enough dose PEA becomes it’s own MAO-I, saturating the enzymes and allowing a significant portion to cross the blood brain barrier. You need to take between 2g-4g depending on body size and personal metabolism for this to work.
