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- It is shown that miR-7a is a key functional RNA sustaining the late phase of neuropathic pain through regulation of neuronal excitability in rats, and miR -7a replenishment offers a novel therapeutic strategy specific for chronic neuropathicPain.
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Jul 16, 2013 · These findings demonstrate miR-7a downregulation is causally involved in maintenance of neuropathic pain through regulation of neuronal excitability, and miR-7a replenishment offers a novel therapeutic strategy specific for chronic neuropathic pain.
- Atsushi Sakai, Fumihito Saitow, Noriko Miyake, Koichi Miyake, Takashi Shimada, Hidenori Suzuki
- 2013
Mar 3, 2023 · However, it emerges that regulation of RASA1 by miRNAs plays an important role in neuropathic pain. miR-206 downregulation is also involved in neuropathic pain through brain-derived neurotrophic factors (BDNF) interaction, leading again to the activation of the MEK/ERK signalling pathway.
- 10.3390/biomedicines11030775
- 2023/03
- Biomedicines. 2023 Mar; 11(3): 775.
Dec 31, 2023 · miR-7a downregulation is causally involved in maintenance of NP through regulation of neuronal excitability, and miR-7a replenishment offers a novel therapeutic strategy specific for chronic NP [272] Qi et al., 2022: In vitro: Identifying miR-32-5p as a key functional noncoding RNA in trigeminal-mediated NP: High-throughput sequencing and qPCR ...
The miRs (miR144, miR206, miR93, miR98, miR544, and miR206) are downregulated during neuropathic pain, according to red downward arrows; in contrast, upward green arrows indicate the elevation of miRs (miR15, miR16, miR155, miR221, and miR7a) during neuropathic pain.
Feb 17, 2023 · Using microarray techniques, recent studies have reported that miRNAs play pivotal roles in the evolution and progression of neuropathic pain by regulating neuronal excitability and plasticity, neuronal ion channels, neuroinflammation, synaptic plasticity and other functions.
- 10.3389/fnmol.2023.1110975
- 2023
- Front Mol Neurosci. 2023; 16: 1110975.
Apr 15, 2019 · However, the upregulation of miR-7a alleviated NEFL-induced neuropathic pain, suggesting that miR-7a attenuates neuropathic pain through downregulation of NEFL. In addition, spinal cord microglia with peripheral nerve damage exhibited activated JAK-STAT3 signaling pathways.
Jul 16, 2013 · neuropathic pain through regulation of neuronal excitability, and miR-7a replenishment offers a novel therapeutic strategy specific for chronic neuropathic pain.
