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Mar 20, 2015 · Abstract. Experimental studies have suggested possible protective effects of dimethylglycine (DMG) on glucose metabolism. DMG is degraded to glycine through a DMG-dehydrogenase (DMGDH)-catalyzed reaction, and this is the only known pathway for the breakdown of DMG in mammals. In this study, we aimed to identify the strongest genetic determinant ...
- Martin Magnusson, Thomas J. Wang, Clary Clish, Gunnar Engström, Peter Nilsson, Robert E. Gerszten, O...
- 10.2337/db14-1863
- 2015
- Diabetes. 2015 Aug; 64(8): 3010-3016.
Nov 19, 2022 · Previous studies have shown that certain lipokines can affect glucose metabolism in adipose, liver, and skeletal muscle tissue 89. ... M. et al. Dimethylglycine deficiency and the development of ...
Oct 31, 2023 · The increase in circulating BAs is not the factor that causes the change in glucose metabolism, but its downstream effect . Recent study has also confirmed that the increase of circulating BAs in T2DM individuals is positively correlated with fasting blood glucose, HbA1c, and HOMA-IR, which may be due to insulin signaling dysfunction.
- Yanzhong Liu, Dan Wang, Yi-Ping Liu
- 2023
- 10.3389/fendo.2023.1237934
Nov 1, 2017 · Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration. In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2 diabetes and higher serum glycine level is associated with decreased risk of incident type 2 diabetes. Consistently, plasma glycine concentration is lower in ...
- M. Adeva-Andany, G. Souto-Adeva, E. Ameneiros-Rodríguez, C. Fernández-Fernández, C. Donapetry-García...
- 2018
Jun 17, 2024 · Results: Glucose intake altered metabolic profile and induced an increase in glycolytic intermediates and a decrease in amino acids, glycerol, ketone bodies, and triglycerides. Isoleucine levels differed between the NGT and NDM groups and between the NGT and IGR groups. Changes in sarcosine levels during the OGTT in the diabetes groups were ...
Mar 15, 2017 · Rather, a stronger link exists between brain glycine and activation of NMDA receptors as a mechanism for glycine’s glucose-lowering effect . The dorsal vagal complex (DVC) is an important region regulating hepatic glucose production and hepatic triglyceride-rich very-low-density lipoprotein (VLDL-TG) production ( 79 ).
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Dimethylglycine is promoted to increase athletic performance and is used in the treatment of autism and as an anti-convulsant. It is metabolized (nitrosated) in the body to produce nitrososarcosine, a weak carcinogen, and also to dimethylnitrosamine, a potent carcinogen. Read more. View chapterExplore book.
