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  2. Registration in PROSPERO involves the prospective submission and publication of key information about the design and conduct of a systematic review. Registration on PROSPERO is free of charge. In return, registrants are accountable for the accuracy and updating of information submitted.

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  3. PROSPERO accepts registrations for systematic reviews, rapid reviews and umbrella reviews. PROSPERO does not accept scoping reviews or literature scans. Sibling PROSPERO sites registers systematic reviews of human studies and systematic reviews of animal studies.

  4. PROSPERO does not accept: Systematic reviews without an outcome of clear relevance to the health of humans. Scoping reviews. Literature reviews that use a systematic search. Systematic reviews assessing sports performance as an outcome. Methodological reviews that assess ONLY the quality of reporting. Systematic critical appraisals.

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    • Strengths and Limitations
    • Comparison with Other Studies
    • Explanations and Implications

    A strength of our study is that the PROSPERO database managers provided us with routinely collected data on the number of PROSPERO registrations and website usage, which removed the potential for errors due to manual data collection. Further, we were able to explore trends in these variables over time, unlike a previous evaluation which was limited...

    Compared with a previous analysis of the characteristics of PROSPERO registrations , the geographical scope of SRs registered has changed considerably over time. Registrations in the first year (2011–2012) came from 33 different countries, whereas that figure has risen to over 100 countries now. England remains the country responsible for most regi...

    The exponential increase in SR registrations from 2011 to 2017 is a surprising, albeit welcome, development. Unlike for clinical trialists, who rapidly embraced trial registration only after the International Committee of Medical Journal Editors (ICMJE) announced that they would no longer publish trials that were not registered at inception , SR re...

    • Matthew J. Page, Larissa Shamseer, Larissa Shamseer, Andrea C. Tricco, Andrea C. Tricco
    • 2018
  5. PROSPERO offers free registration and free public access to a unique prospective register of systematic reviews across all areas of health from all around the world. The dedicated web-based interface is electronically searchable and available to all prospective registrants.

  6. Jan 8, 2022 · Overall, we describe five options to prospectively register a systematic review: PROSPERO, the Registry of Systematic Reviews/Meta-Analyses in Research Registry, and INPLASY, which are specific to systematic reviews, and Open Science Framework (OSF) Registries and protocols.io, which present generic registers open to any study type.

  7. PROSPERO compiles a comprehensive listing of systematic review protocols in an attempt to avoid duplication of effort, reduce reporting bias, and promote transparency. Keywords: Evidence-based practice; health sciences database; product evaluation; search engine.

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