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May 16, 2022 · The most common complaint associated with statins, according to the American College of Cardiology, is myopathy, a muscle disorder, which may occur in up to a third of statin users....
Statins are a cornerstone in the pharmacological prevention of cardiovascular disease. Although generally well tolerated, a small subset of patients experience statin-related myotoxicity (SRM). SRM is heterogeneous in presentation; phenotypes ...
Dec 20, 2019 · Although generally well tolerated, a small subset of patients experience statin-related myotoxicity (SRM). SRM is heterogeneous in presentation; phenotypes include the relatively more common myalgias, infrequent myopathies, and rare rhabdomyolysis.
- Richard Myles Turner, Munir Pirmohamed
- 2019
Evidence to date indicates that statins can cause either self-limited myotoxicity, presumably due to the direct effect of statins in the muscle, or an autoimmune myopathy associated with autoantibodies targeting HMGCR.
Apr 22, 2024 · Diagnosis relies on having a high clinical suspicion and being aware of the clinical phenotype associated with certain drugs. This topic will review the clinical and laboratory features of drug-induced myopathy. Rhabdomyolysis and statin myopathy are discussed in detail separately.
Primary prevention. A recent large meta-analysis by Yebyo et al. in 2019 15 revealed that the risk of non-fatal myocardial infarction was significantly reduced with statins as a class effect (relative risk: 0.62; 95% confidence interval [CI]: 0.53–0.72) compared with placebo.
Oct 14, 2016 · Muscle disorders provoked by statin use have been named “statin-associated myopathy (SAM)”. There is no commonly accepted definition of SAM, although recently a score system was introduced and the European Atherosclerosis Society (EAS) proposed a definition of SAM.
