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Generalized anxiety disorder is one of the most common anxiety disorders and can be costly if unrecognized or left untreated. Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from GAD. This systematic review evaluates the effectiveness of azapirones compared to other treatments.
Symptoms of generalised anxiety disorder (GAD) The main symptom of generalised anxiety disorder (GAD) is feelings of stress or worry that affect your daily life and are difficult to control. Other symptoms of GAD may include: difficulty sleeping. feeling restless, irritable or finding it difficult to concentrate. getting tired easily.
Nov 1, 2023 · Noteworthy, the putative mechanisms of action of the “drugs used in the treatment of depression” (and anxiety) are broad to such an extent that neuroscience, rather than a class-based, nomenclature approach, has been promoted by the European Neuropsychopharmacology Association through the present Journal (Zohar and Levy, 2022; Zohar et al., 2015).
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Jul 19, 2006 · Abstract. Background: Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder (GAD). However, several studies have shown conflicting results. Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered.
Nov 1, 2023 · The present SR and meta-analysis is the first to assess azapirones’ efficacy for anxiety disorders. Compared to the most current meta-analyses on the matter (Chessick et al., 2006; Imai et al., 2014), the present report not only accounts for anxiety disorders other than GAD and PD but also provides an up-to-date evaluation of azapirones in such disorders, different outcomes, and GRADE ...
Jul 31, 2017 · Although the dopaminergic theory of azapirone action remains unproven, evidence in humans is emerging to confirm that standard therapeutic doses of azapirones such as buspirone can achieve significant D3 receptor occupancy . Finally, azapirone inhibition of α2‐adrenoceptors on serotonergic neurons may also play a role in the anxiolytic effects of buspirone.
Jun 17, 2021 · In this review, the author examines the evidence for psychopharmacologic treatments among adults for generalized anxiety disorder, panic disorder, and social anxiety disorder derived from clinical trials. For each disorder, major categories of drugs are reviewed, and then the evidence-based medications in each category are discussed. The author reviews key safety and tolerability ...
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