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  1. Common side effects of Z drugs include: 5-7. Drowsiness, sometimes lasting into the day after taking the medicine. Light-headedness or dizziness. Headache. Dry mouth or a bad taste in the mouth. Diarrhea. Skin rash. Infections. All Z drugs have a boxed warning, the strictest warning from the FDA.

    • What Are Benzodiazepines?
    • What Are Benzodiazepines and Z Drugs Used for?
    • How Effective Are Benzodiazepines and Z Drugs?
    • Why Should Benzodiazepine and Z Drugs Be Used only For A Short time?
    • What Happens If You Use A Benzodiazepine Or A Z Drug For Longer?
    • Some Other Possible Problems with Benzodiazepines and Z Drugs
    • Benzodiazepines and Z Drugs and The Law
    • What If I Have Been Taking A Benzodiazepine Or A Z Drug For A Long time?
    • How Should I Stop Taking A Long-Term Benzodiazepine Or Z Drug?
    • Some Tips That May Help

    How do benzodiazepines work?

    Benzodiazepines work by affecting the way certain brain chemicals (neurotransmitters) transmit messages to certain brain cells. In effect, they decrease the excitability of many brain cells. This has a calming effect on various functions of the brain.

    Benzodiazepines for anxiety

    Symptoms of anxietyinclude: agitation, tension, irritability, the sensation of having a 'thumping heart' (palpitations), shakiness, sweating, excess worry, sleeping badly, poor concentration, fast breathing and sometimes a knotted feeling in the stomach and other muscles. There are various causes of anxiety. Sometimes it is a sudden life crisis such as a bereavement or redundancy. Some people have an anxious personality and feel anxious fairly often. Sometimes anxiety can be one of the sympto...

    Benzodiazepines and Z drugs as sleeping tablets

    A short course of a benzodiazepine or a Z drug may be prescribed if a medicine is felt necessary to help with sleeping difficulty (treatment for insomnia). However, there are other ways of helping to get a good night's sleep. See also the separate leaflet called Insomnia (Poor Sleep).

    Other uses of benzodiazepines

    A dose of benzodiazepines is often given as a 'pre-med' to reduce anxiety before an operation. A large dose is commonly given as a sedative during medical procedures that may cause anxiety or discomfort. The medicine not only reduces anxiety but also has an amnesic effect. This means that you do not remember much about the procedure afterwards. Some benzodiazepines are occasionally used to treat muscle spasm and certain types of epilepsy as they can prevent fits (seizures). Others are used to...

    If you are not used to taking benzodiazepines or Z drugs, the first doses are usually good at easing symptoms of anxiety or promoting sleep. A benzodiazepine does nothing to remove any underlying cause of anxiety such as a life crisis. However, if your symptoms are eased, you may be able to cope better with any problems. Benzodiazepines and Z drugs...

    When benzodiazepines were first used they were thought to be safe. The problems with their long-term use were not known. In 1981, benzodiazepines were the most commonly prescribed medicines in western countries. It was because benzodiazepines worked so well to ease symptoms of anxiety and poor sleep that many people came back for more. Some people ...

    Tolerance

    If you take a benzodiazepine or Z drug regularly, the helpful effect on easing anxiety or in helping sleep usually lasts for a few weeks. However, after a few weeks, the body and brain often become used to the benzodiazepine or Z drug. The medicine then gradually loses its effect. The initial dose then has little effect. You then need a higher dose for it to work. In time, the higher dose does not work and you need an even higher dose and so on. This effect is called tolerance.

    Dependence

    There is a good chance that you will become addicted to (dependent on) a benzodiazepine or a Z drug if you take it for more than four weeks. This means that withdrawal symptoms occur if the tablets are stopped suddenly. In effect, you need the medicine to feel normal. Possible withdrawal symptoms include: 1. Psychological symptoms - such as anxiety, panic attacks, odd sensations, feeling as if you are outside your body, feelings of unreality, or just feeling awful. Rarely, a serious mental br...

    Even if you take a benzodiazepine or Z drug for a short time, you may feel drowsy during the daytime. Some people, especially older people, are at greater risk of having a fall and injury because of the drowsiness. If you drive, you may be more likely to be involved in a car crash. Some people have described themselves as being in a zombie state wh...

    Benzodiazepines and Z drugs can sometimes be misused by people taking drugs for recreational purposes. The Misuse of Drugs Act was a law passed in 1971 in the UK to try to prevent the use of harmful drugs. It divides drugs into three categories - A, B or C, depending on how dangerous they are thought to be. Each of the categories then has different...

    If you have been taking a benzodiazepine or a Z drug for over four weeks and want to come off it, it is best to discuss the problem with a doctor. Some people can stop taking benzodiazepines or Z drugs with little difficulty. However, many people develop withdrawal symptoms if they suddenly stop taking a benzodiazepine or a Z drug. To keep withdraw...

    If you have been taking a benzodiazepine or Z drug for over four weeks and want to stop it, it is best to discuss the problem with a doctor. Some people can stop taking benzodiazepines and Z drugs without any difficulty, as they have only minor withdrawal effects which soon ease off. However, for a lot of people the withdrawal effects are too sever...

    Before coming off a benzodiazepine or a Z drug it may be best to wait until any life crisis has passed and your level of stress is as low as can be.
    Consider starting whilst on holiday, when you have less pressure from work, fewer family commitments, less stress, etc.
    Consider telling family or friends that you are coming off a benzodiazepine or a Z drug. They may give you encouragement and support.
    Consider joining a local self-help group. Advice and support from other people in similar circumstances, or who have come off a benzodiazepine or a Z drug, can be very encouraging.
  2. Jun 15, 2023 · News 15 June 2023. People who have been prescribed sleeping medications benzodiazepines and Z-drugs (zolpidem or zopiclone) could benefit from a new patient decision aid designed to help them make an informed choice about their treatment in discussion with their GP or pharmacist. NICE has today (Thursday, 15 June) published a patient decision ...

  3. www.mind.org.uk › information-support › drugs-andSleeping pills - Mind

    The Z drugs are non-benzodiazepine sleeping pills, used to treat severe insomnia (difficulty getting to sleep or staying asleep). They are known as the Z drugs because their generic names begin with the letter ‘z'. The Z drugs currently licensed for prescription in the UK are zolpidem and zopiclone.

  4. Mar 6, 2024 · But as with any medicine, there are risks. Prescription Z-drugs work by slowing activity in the brain. Used properly, they can help you sleep. Quality sleep can have a positive impact on physical ...

  5. Z-drugs licensed for the short-term management of insomnia include: Zopiclone. In adults — 7.5 mg once daily at bedtime. In the elderly (avoid if possible due to increased risk of adverse effects) — if essential, use a lower dose; initially 3.75 mg once daily at bedtime. DO NOT re-administer during the same night. Zolpidem.

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  7. Feb 1, 2022 · Background Z-drugs are usually prescribed as first line pharmacological therapy for insomnia. However, the benefits and risks of Z-drugs may differ for older adults. This systematic review investigated the available evidence on the efficacy and safety of Z-drugs in the management of insomnia in older adults. Methods The Cochrane database of Systematic Reviews, the Cochrane Central Register of ...

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