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- These drugs should be avoided or used very carefully in patients with liver disease.
bnf.nice.org.uk/medicines-guidance/prescribing-in-hepatic-impairment/Prescribing in hepatic impairment | Medicines guidance | BNF ...
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Are proton pump inhibitors safe in patients with cirrhosis?
Jun 21, 2013 · Proton-pump inhibitors and, to a lesser degree, histamine-2 blockers have recently been associated with serious infections in patients with cirrhosis, so clinicians should limit their use to valid indications.
- Atif Zaman
- 2013
In people with this advanced disease, we need to consider whether we can do anything to stop or reverse the liver damage. For example stopping alcohol or treating viral hepatitis. We also want to prevent further complications such as bleeding from varices (veins in the gullet or stomach).
Oedema and ascites in chronic liver disease can be exacerbated by drugs that give rise to fluid retention e.g. NSAIDs and corticosteroids.
Jun 7, 2018 · We suggest using esomeprazole, omeprazole or rabeprazole in patients with CTP A or B cirrhosis and only esomeprazole in patients with CTP C. Pharmacokinetic changes are also important to consider when prescribing PPIs to vulnerable, cirrhotic patients. Keywords: drug safety, evidence‐based medicine, hepatology, liver.
- Rianne A. Weersink, Margriet Bouma, David M. Burger, Joost P.H. Drenth, S. Froukje Harkes‐Idzinga, N...
- 10.1111/bcp.13615
- 2018
- 2018/08
This leaflet highlights the most common medication that can be used. You may be prescribed one or more of the medicines discussed in this leaflet. Hepatic encephalopathy. When the liver is working well, it can help get rid of waste products from your body.
The treatment for cirrhosis depends on what has caused it. Cirrhosis cannot usually be cured, but there are ways to manage the symptoms and any complications, and stop the condition getting worse.
Jul 18, 2023 · Antiepileptic drugs in liver cirrhosis or renal impairment. ”The primary objective of this review is to focus on AED selection and on dosing and interval changes that may be necessary due to altered drug metabolism and renal excretion in hepatic or renal disease.