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      • Odds ratios are always a distortion of their corresponding risk ratios. The extent of the distortion depends on the frequency of the outcome under study and the size of the effect (see In-Depth box for mathematical details).
      onlinelibrary.wiley.com/doi/full/10.1016/j.pmrj.2011.01.009
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  2. APPROXIMATION OF THE RISK RATIO? Odds ratios are always a distortion of their corresponding risk ratios. The extent of the distortion depends on the frequency of the outcome under study and the size of the effect (see In-Depth box for mathematical details). When the outcome is rare, the distortion is small; in this case, the

  3. Jan 24, 2014 · This paper provides practical advice for authors and readers on converting odds ratios to relative risks. The odds ratio is a common measure in medical research of the effect size comparing two groups (treatments or risk factors) in terms of an outcome that is either present or absent.

    • Robert L Grant
    • 2014
  4. When the probabilities are small, odds ratios and relative risk ratios are nearly identical, but they can diverge widely for large probabilities. The magnitude of the odds ratio is hard to interpret because of the arbitrary scaling factor and cannot be compared with odds ratios from other studies.

    • Edward C. Norton, Bryan E. Dowd, Matthew L. Maciejewski
    • 2018
  5. Apr 1, 2020 · Odds ratios (ORs) are often interpreted as risk ratios in longitudinal cohort studies and clinical trials, but this practice is misleading when the outcome is common (>10%). ORs rapidly diverge from risk ratios as outcome frequency increases, which results in overestimation of the risk ratio [[1], [2], [3]].

    • Tzu-Chun Chu, Tzu-Chun Chu, Rohit P. Ojha, Rohit P. Ojha, Tyler J. VanderWeele
    • 2020
  6. Odds ratios (OR) are commonly reported in the medical literature as the measure of association between exposure and outcome. However, it is relative risk that people more intuitively understand as a measure of association.

  7. Aug 9, 2023 · The odds ratio is mathematically similar to the risk ratio when the outcome is rare, because A+B will be similar to B, and C+D will be similar to D. But when the outcome is common, the odds ratio and risk ratio can be very different.1.

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