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Mar 1, 2002 · Proteoglycans are a family of glycoconjugates with a central core protein to which one or more glycosaminoglycan (GAG) side chains are covalently linked post-translationally 3.
- Chris Kiani, Liwen Chen, Yao Jiong Wu, Albert J Yee, Burton B Yang
- 2002
The cell surface and connective matrix of animal tissues have large proteoglycan molecules, which have covalently attached glycosaminoglycan chains (GAGs) that may be either N-linked or O-linked to the core protein.
In nature, all GAG chains with the exception of HA are covalently linked to a core protein to give a PG. The linkage of GAGs to the protein core involves a specific trisaccharide composed of two galactose (Gal) residues and a xylose (Xyl) residue (GAG-GalGalXyl-O-CH 2-protein).
- Neha S. Gandhi, Ricardo L. Mancera
- 2008
Glycosaminoglycans (GAGs) are large linear polysaccharides constructed of repeating disaccharide units with the primary configurations containing an amino sugar (either GlcNAc or GalNAc) and an uronic acid (either glucuronic acid and/or iduronic acid). There are five identified glycosaminoglycan chains (Figure 1): Hyaluronan.
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural diversity and fulfilling various functions mediated by thousands of interactions in the extracellular matrix, at the cell surface, and within the cells where they have been detected in the nucleus.
Apr 23, 2020 · Sulfated glycosaminoglycans (GAGs) are a family of linear polysaccharides covalently attached to core proteins, and are the glycan part of PGs (6). Mammals express five sulfated GAGs that differ in their backbone structure and sulfation pattern: heparin, HS, CS, DS, and KS.
Oct 5, 2021 · GAGs coat the cell surface through a covalent linkage to protein cores, forming sulfated proteoglycans, including syndecans (transmembrane), glypicans (GPI; glycosylphosphatidylinositol anchored), and perlecan in the extracellular matrix.
