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Sep 20, 2023 · In the present study, to investigate whether a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PH) inhibitor, FG-4592 (also called roxadustat), has neuroprotective effects against α-Syn-induced neurotoxicity, we employed a novel α-Syn stably expressing cell line (named α-Syn-N2a cells) utilizing a piggyBac transposon system.
- 10.1038/s41598-023-42903-7
- 2023
- Sci Rep. 2023; 13: 15629.
Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its molecular path-ogenesis, however, is poorly understood, with no useful biomarkers available for accurate diagnosis and mo-lecular classification.
Yoichi Maekawa currently works at the Department of Parasitology and Infectious Diseases, Gifu University. Yoichi does research in Infectious Diseases, Cancer Research and Cell Biology.
Mie University Graduate School & Faculty of Bioresources Website
According to the mutational status of TP53, MDM2, RAS, and FGFR3, UTUC is classified into five subtypes having discrete profiles of gene expression, tumor location/histology, and clinical outcome, which is largely recapitulated in an independent UTUC cohort.
- Yoichi Fujii, Yusuke Sato, Hiromichi Suzuki, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Andrew T. Lenis...
- 2021
1 day ago · In the context of cisplatin-induced AKI, damaged DNA and mtDNA leak into the cytoplasm, thereby triggering inflammatory responses and tissue damage through the activation of the cGAS-STING cascade (X. Gao et al., 2023; Gong et al., 2021; Maekawa et al., 2019). The knockdown of STING has been demonstrated to significantly ameliorate cisplatin-induced renal inflammatory injury and renal ...
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